Objective
This project will offer postdoctoral scientists the opportunity to acquire knowledge and experimental expertise from synthetic organic chemistry to occurring at the active sites of coenzyme B12-dependent enzymes. This will be achieved by an interdisciplinary approach using the complimentary skills molecular biology. Such interdisciplinary training is of increasing importance to the European pharmaceutical industry, enabling it to maintain of seven leading European laboratories. The combined B12 group will be the its competitive edge.
strongest in the world. Specific goals are:
* Structure determination of B12-dependent enzymes and protein fragments * Preparation of modified enzymes by site directed mutagenesis; evaluation of their catalytic efficiency
* Synthesis of coenzyme analogues, preparation of enzyme-coenzyme analogue complexes and evaluation of their catalytic efficiency
* Synthesis of substrate analogues and evaluation of their inhibitory properties
* Characterisation by spectroscopic techniques (NMR, EPR) of enzymes and enzyme-coenzyme complexes, in the presence and absence of substrates and inhibitors
* Development of functional models for B12-dependent enzymic reactions. The project builds on a current successful collaboration of four of the laboratories, which has provided new insights into the B12 mechanistic problem.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences organic chemistry
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- natural sciences biological sciences molecular biology
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Data not available
Coordinator
NE1 7RU NEWCASTLE UPON TYNE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.