Objective The hepatitis c virus (hcv) is a major cause for chronic liver disease world-wide. Present therapies based on alpha-interferon and ribavirin can induce a sustained virologicaland biochemical response in 30-70 % of the patients. Thus, additional regimens are needed to improve treatment for chronic hcv infections. T cells have been found to play a central role in the clearence of hcv infections. A major problem is the high degree of genetic variability of hcv which probably caused the characterize hcv-specific vaccines based on the most conserved hcv proteins (core and ns3) by cloning genes from infected patients. These genes will form the base for recombinant proteins, synthetic peptides and genetic immunogens to be analysed in wild-type and transgenic mouse models. This proposal aim at to defining the optimal gene (s), the most potent vehicule, and the best route of delivery. Fields of science natural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencesinfectious diseasesRNA viruseshepatitis Cnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesclinical medicinehepatology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-2. - Key action Control of Infectious Diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator KAROLINSKA INSTITUTE EU contribution No data Address Solnavagen 1 171 77 STOCKHOLM Sweden See on map Total cost No data Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all FUNDACION JIMENEZ DIAZ Spain EU contribution No data Address Avenida Reyes Catolicos 2 28040 MADRID See on map Total cost No data FUNDACION PARA EL ESTUDIO DE LAS HEPATITIS VIRALES Spain EU contribution No data Address c/ Guzman el Bueno 72 28015 MADRID See on map Total cost No data GENT UNIVERSITY Belgium EU contribution No data Address Sint Pietersnieuwstraat 25 9000 GENT See on map Total cost No data
