Objective The aim of this project is to develop a protein-based subunit vaccine against diseases caused by S. pneumonia by preventing its colonisation of the human nasopharinx. Target antigens will be identified among surface proteins which act as adhesins. The first years will be devoted to the discovery of new adhesins and to determine the degree of their allelic/antigenic variation. The role of putative adhesins, selected via genomics and bioinformatics, will be tested using single and combined knock-out mutants in adhesion assays and in a mouse pharyngeal colonization model. Mouse immunization studies will be performed using purified recombinant proteins and the live vaccine vector S.gordonii. Mucosal delivery will be by the nasal route and by colonization of the upper respiratory tract with the live vector. Protection from colonization and from invasive disease will be evaluated, together with the local and systemic immune responses. Fields of science medical and health sciencesclinical medicinepneumologymedical and health sciencesbasic medicineimmunologyimmunisationnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY OF KEELE EU contribution No data Address Keele University ST5 5BG STAFFORDSHIRE United Kingdom See on map Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all BIOCOMPOSITES LIMITED United Kingdom EU contribution No data Address Etruscan Street Etruria ST1 5PQQ Stoke-on-Trent See on map Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution No data Address 146,Rue Léo Saignat 146 ADR9 - Aquitaine, Université 33076 Bordeaux See on map Total cost No data LINKOEPING UNIVERSITY Sweden EU contribution No data Address Hus Origo Campus Valla 581 83 LINKOEPING See on map Total cost No data THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN Ireland EU contribution No data Address Trinity College 2 DUBLIN See on map Total cost No data UNIVERSITY OF GENOVA Italy EU contribution No data Address Via Balbi 5 16126 GENOVA See on map Total cost No data UNIVERSITY OF GLASGOW United Kingdom EU contribution No data Address University Avenue GLASGOW See on map Total cost No data Birkbeck College, University of London United Kingdom EU contribution No data Address Malet Street, Bloomsbury WC1E 7HX London See on map Total cost No data VRIJE UNIVERSITEIT AMSTERDAM - VERENIGING VOOR CHRISTELIJK WETENSCHAPPELIJK ONDERWIJS Netherlands EU contribution No data Address De Boelelaan 1105 1081 HV AMSTERDAM See on map Total cost No data
