Objective Our aim is to link non-invasive imaging and nucleic acid biotechnology to create new in vivo imaging methods. Oligonucleotide ligands termed aptamers bind with high affinity biological targets and can be obtained from large combinatorial libraries. Modified aptamers engineered to resist degradation and target molecular markers of disease are thus promising candidates both as diagnostic tools and as therapeutic agents. Using non-invasive imaging procedures (PET) , we will evaluate in animal models of disease the potential of stable aptamers for diagnostic and therapy. This project merges 6 groups specialized in the following fields:i) biologically-stable aptamer production (including a leading biotech company);ii) study of biomarkers in animal disease models, andiii) in vivo imaging methods. The major spin-off expected is the creation of generic methods for diagnosis and evaluation of new therapies. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acids Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITE DE PARIS-SUD XI EU contribution No data Address RUE GEORGES CLEMENCEAU 15 91405 ORSAY France See on map Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address Avenue de la Terrasse, BFtiment 26 91198 GIF SUR YVETTE See on map Total cost No data CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution No data Address Rosello 161 08036 BARCELONA See on map Total cost No data HOSPITAL CLINIC BARCELONA Spain EU contribution No data Address Villaroel 170 08036 BARCELONA See on map Total cost No data NATIONAL RESEARCH COUNCIL OF ITALY Italy EU contribution No data Address Via Sergio Pansini 5 80131 NAPOLI See on map Total cost No data NOXXON PHARMA AG Germany EU contribution No data Address Gustav-Meyer-Allee 25 13355 BERLIN See on map Total cost No data UNIVERSITY OF TORINO Italy EU contribution No data Address Via Santena 19 10126 TORINO (TURIN) See on map Total cost No data
