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Control of specification and migration of oligodendrocytes

Objetivo

The study of cellular and molecular mechanisms underlying oligodendrocytedevelopment is a prerequisite to understand pathologies linked to myelin dysfunction. During development, the oligodendroglial specification of intraepithelial cells is a process spatially restricted which gives rise to a diversity of oligodendrocyte cells types. The aim of our project is to study, from multidisciplinary approaches (molecular and cellular) and in different animal models (Drosophilae, chick, mouse):
i) the developmental mechanisms regulating the oligodendrogenesis from undifferentiated intraepithelial precursors: focusing on genetic cascade that controls the choice of oligodendroglial lineage; and
ii) the biological consequences of molecular and spatial differentiate characters of oligodendrocyte progenitors; focusing the migration patterns and their molecular control.

Convocatoria de propuestas

Data not available

Régimen de financiación

CSC - Cost-sharing contracts

Coordinador

UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
Aportación de la UE
Sin datos
Dirección
Campus de San Juan - Ctra Alicante-Valencia Km 8,7
03550 SAN JUAN DE ALICANTE
España

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Coste total
Sin datos

Participantes (6)