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Control of specification and migration of oligodendrocytes

Objective

The study of cellular and molecular mechanisms underlying oligodendrocytedevelopment is a prerequisite to understand pathologies linked to myelin dysfunction. During development, the oligodendroglial specification of intraepithelial cells is a process spatially restricted which gives rise to a diversity of oligodendrocyte cells types. The aim of our project is to study, from multidisciplinary approaches (molecular and cellular) and in different animal models (Drosophilae, chick, mouse):
i) the developmental mechanisms regulating the oligodendrogenesis from undifferentiated intraepithelial precursors: focusing on genetic cascade that controls the choice of oligodendroglial lineage; and
ii) the biological consequences of molecular and spatial differentiate characters of oligodendrocyte progenitors; focusing the migration patterns and their molecular control.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
Address
Campus De San Juan - Ctra Alicante-valencia Km 8,7
03550 San Juan De Alicante
Spain

Participants (6)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
118 Route De Narbonne
31062 Toulouse
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Boulevard Del'hôpital 47 Hôpital De La Salpétrière
75651 Paris
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Germany
Address
Hermann-rein-strasse 3
37075 Göttingen
UNIVERSITE PAUL SABATIER DE TOULOUSE III
France
Address
Route De Narbonne 118
31062 Toulouse
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
The Cruciform Building, Gower Street
WC1E 6BT London
WESTFAELISCHE WILHELMS - UNIVERSITAET MUENSTER
Germany
Address
Badestr. 9
48149 Münster