Objective The use of dendrite cells (DC) as natural adjuvant has been proposed. Aim of this project is the delivery of new therapeutic treatments of human papillomavirus (HPV) injection. The proposed strategy torn immune cell therapy is based on the use of dendrite cells (DC), which are known to be the most powerful professional antigen presenting cells of the immune system, able to prime and activate antigen-specific immune responses. The most relevant objectives are:1) the generation of vectors for appropriable delivery of viral antigens to DC;2) the generation of modified DC;3) the evaluation of safety and efficacy of modified DC therapy in pre-clinical model of virally-inducedtumors;4) Pilot clinical trial of HPV patients with antilogous DC loaded with HPV antigens. This project aims to generate a novel therapeutically strategy which requires a broad interdisciplinary approach. The proposed DC-based therapy demands the generation and validation of new therapeutic tools. One SME will contribute to the pre-clinical studies in order to be in a favourable position to exploit the results of the project. Fields of science medical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicineoncologycervical cancermedical and health scienceshealth sciencesinfectious diseasesDNA virusesmedical and health sciencesmedical biotechnologycells technologies Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-2. - Key action Control of Infectious Diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA EU contribution No data Address Piazza della Scienza 2 20126 MILANO Italy See on map Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all ACADEMISCH ZIEKENHUIS LEIDEN Netherlands EU contribution No data Address Albinusdreef 2 2333 RC LEIDEN See on map Total cost No data ANOSYS S.A. France EU contribution No data Address Rue Pierre Fontaine, 1 91058 EVRY See on map Total cost No data BIOPOLO SCRL Italy EU contribution No data Address Piazza della Scienza 2 20126 MILANO See on map Total cost No data FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR - ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO Italy EU contribution No data Address Via Olgettina 60 HSR Parco Scientifico 20132 MILANO See on map Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution No data Address John Radcliffe Hospital - Oxfordshire 5802 OX3 9DU OXFORD/HEADINGTON See on map Total cost No data UNIVERSITY OF ERLANGEN-NUREMBERG Germany EU contribution No data Address 14,Hartmannstrasse 14 91052 Erlangen See on map Total cost No data
