Objectif PM10 and PM2, 5 ambient particulate fractions collected in Amsterdam, Lodi, Oslo and Rome and the Dutch sea-side will be characterised by physical-chemical and immunological parameters. The samples will be screened for respiratory allergic and inflammatory potential and positive findings will undergo verification in vivo respiratory allergic and inflammatory models. Mechanisms underlying modulation of molecular and cellular functions of the immune system, of signalling pathways in rat and human epithelial lung cell cultures, and of in vivo respiratory immune responses will be clarified. Mechanistic information is important for extrapolating the results from the experimental models to the human situation. The outcome of these studies will be communicated to policymakers, the public and industry as basis for preventive action. Champ scientifique medical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicineallergology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Thème(s) 1.1.1.-4. - Key action Environment and Health Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur NORWEGIAN INSTITUTE OF PUBLIC HEALTH Contribution de l’UE Aucune donnée Adresse 0403 OSLO Norvège Voir sur la carte Coût total Aucune donnée Participants (3) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire NATIONAL INSTITUTE OF PUBLIC HEALTH AND ENVIRONMENT Pays-Bas Contribution de l’UE Aucune donnée Adresse Antonie van Leeuwenhoeklaan 9 3720 BA BILTHOVEN Voir sur la carte Coût total Aucune donnée THE NOFER INSTITUTE OF OCCUPATIONAL MEDICINE Pologne Contribution de l’UE Aucune donnée Adresse Teresy Street 8 90 950 LODZ Voir sur la carte Coût total Aucune donnée WORLD HEALTH ORGANIZATION Italie Contribution de l’UE Aucune donnée Adresse via Francesco Crispi, 10 00187 ROMA Voir sur la carte Coût total Aucune donnée