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European multiple system atrophy study group

Objective

Multiple system atrophy (MSA) is a progressive neurodegenerative disorder, which frequently presents with the features of Parkinson's Disease, but in contrast to latter, causes early death and prolonged severe disability. The proposed concerted action will pave the way towards neuroprotective intervention trials in MSA by developing a trial protocol 'CAPIT-MSA) and by implementing a central MSA Registry (EMSA-R) for centralized data acquisition during a multicoated natural history study that will enable us to define rates of disease progression and to validate the CAPIT-MSA protocol. Furthermore, candidate neuroprotective agents will be screened in proof of concept studies using an established animal model of striatonigral degeneration. Pending ongoing preclinical safety and phase I studies of these agents by the industrial partners, one of the agents will be selected foray multicoated safety and tolerability phase II trial commencing at month 18.

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Call for proposal

Data not available

Funding Scheme

CON - Coordination of research actions

Coordinator

UNIVERSITY HOSPITAL INNSBRUCK
EU contribution
No data
Address
Anichstrasse 35
6020 INNSBRUCK
Austria

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Participants (20)

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Last update: 12 April 2005

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Permalink: https://cordis.europa.eu/project/id/QLK6-CT-2000-00661

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