Obiettivo
Multiple system atrophy (MSA) is a progressive neurodegenerative disorder, which frequently presents with the features of Parkinson's Disease, but in contrast to latter, causes early death and prolonged severe disability. The proposed concerted action will pave the way towards neuroprotective intervention trials in MSA by developing a trial protocol 'CAPIT-MSA) and by implementing a central MSA Registry (EMSA-R) for centralized data acquisition during a multicoated natural history study that will enable us to define rates of disease progression and to validate the CAPIT-MSA protocol. Furthermore, candidate neuroprotective agents will be screened in proof of concept studies using an established animal model of striatonigral degeneration. Pending ongoing preclinical safety and phase I studies of these agents by the industrial partners, one of the agents will be selected foray multicoated safety and tolerability phase II trial commencing at month 18.
Campo scientifico
Invito a presentare proposte
Data not availableMeccanismo di finanziamento
CON - Coordination of research actionsCoordinatore
6020 INNSBRUCK
Austria
Mostra sulla mappa
Partecipanti (20)
8000 AARHUS C
Mostra sulla mappa
33076 BORDEAUX
Mostra sulla mappa
38043 GRENOBLE
Mostra sulla mappa
1699 LISBOA
Mostra sulla mappa
W12 0NN LONDON
Mostra sulla mappa
31059 TOULOUSE
Mostra sulla mappa
81377 MUENCHEN
Mostra sulla mappa
221 84 LUND
Mostra sulla mappa
35039 MARBURG
Mostra sulla mappa
53105 BONN
Mostra sulla mappa
13342 BERLIN
Mostra sulla mappa
64239 TEL AVIV
Mostra sulla mappa
NETANYA
Mostra sulla mappa
08036 BARCELONA
Mostra sulla mappa
WC1N 3BG LONDON
Mostra sulla mappa
WC1N 3BG LONDON
Mostra sulla mappa
39008 SANTANDER
Mostra sulla mappa
1525 LJUBLJANA
Mostra sulla mappa
00185 ROMA
Mostra sulla mappa
751 85 UPPSALA
Mostra sulla mappa