Objectif The pace at which sequence information is generated in various model organisms is rapidly growing. However, the ability to generate genetic information has far outstripped our ability analyse it to the point that it is medically relevant. Clearly, functional genomic analyses might benefit from 1) novel genetic models, whose purpose is to complement existing models to obtain comprehensive genetic data on the functional level; and 2) methodology that can bridge the gap between genotype and phenotype in order to understand gene function in vertebrate organisms. Accordingly, we propose to lay the foundation of using Xenopustropicalis as a vertebrate model system for biomedical research by developing transposable elements as molecular tools for functional genomics. In this project we propose to cover the full spectrum of gene analysis by 1) developing efficient transposable element vectors for the introduction of nucleic acid into frog chromosomes; 2) applying transposon technology to efficiently inactivate and rapidly isolate genes in the amphibian model; 3) applying transpose on technology to express genes in different tissues of the amphibian model in order to establish gene function and involvement of gene products in cellular pathways. Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acidsnatural sciencesbiological sciencesgeneticschromosomes Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Thème(s) 1.1.1.-8. - Research into genomes and diseases of genetic origin Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur MAX DELBRUCK CENTER FOR MOLECULAR MEDICINE Contribution de l’UE Aucune donnée Adresse ROBERT-ROESSLE-STRASSE 10 13092 BERLIN Allemagne Voir sur la carte Coût total Aucune donnée Participants (4) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France Contribution de l’UE Aucune donnée Adresse Avenue de la Terrasse, BFtiment 26 91198 GIF SUR YVETTE Voir sur la carte Coût total Aucune donnée CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France Contribution de l’UE Aucune donnée Adresse Rue Cuvier 7 75231 PARIS Voir sur la carte Coût total Aucune donnée MUSEUM NATIONAL D'HISTOIRE NATURELLE France Contribution de l’UE Aucune donnée Adresse Rue Cuvier 7 75231 PARIS Voir sur la carte Coût total Aucune donnée University of Cambridge Royaume-Uni Contribution de l’UE Aucune donnée Adresse Tennis Court Road CB2 1QR Cambridge Voir sur la carte Coût total Aucune donnée
