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Placental uptake and transfer of environmental chemicals relating to allergy in childhood years

Project information

Grant agreement ID: QLK4-CT-2000-00279

  • Start date

    1 March 2001

  • End date

    28 February 2006

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 132 298

  • EU contribution

    € 1 566 192

Coordinated by:

UNIVERSITY OF BRISTOL

United Kingdom

Objective

Increasing pollution and contamination of the environment with xenobiotics may be linked to the increasing prevalence of allergic diseases throughout Europe. The hypothesis addressed by this proposal is that maternal environmental exposure to xenobiotics during pregnancy triggers intrauterine sensitisation and modulation of placental enzyme and immune function. Resulting unbalanced cytokine production will affect the immunoregulation of the placenta and may initiate an allergic reaction following further exposure in childhood resulting in higher levels of clinical allergy in children postnatal. Extent of placental transfer and fatal uptake of xenobiotics will be measured directly with a human perused placenta model and these data will be correlated with epidemiological information on the development of allergy in maternally exposed children.

Coordinator

UNIVERSITY OF BRISTOL

Address

Horsfield Road Bristol Oncology Centre
Bs2 8ed Bristol

United Kingdom

Participants (7)

COMENIUS UNIVERSITY

Slovakia

NATIONAL INSTITUTE FOR RESEARCH AND DEVELOPMENT FOR ENVIRONMENTAL PROTECTION

Romania

SLOVAK MEDICAL UNIVERSITY

Slovakia

Slovak Postgraduate Academy of Medicine

Slovakia

UNIVERSITAIRE INSTELLING ANTWERPEN - UNIVERSITEIT ANTWERPEN

Belgium

UNIVERSITY OF MEDICINE AND PHARMACY 'CAROL DAVILA' IN BUCHAREST

Romania

VITO - VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK NV

Belgium

Project information

Grant agreement ID: QLK4-CT-2000-00279

  • Start date

    1 March 2001

  • End date

    28 February 2006

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 132 298

  • EU contribution

    € 1 566 192

Coordinated by:

UNIVERSITY OF BRISTOL

United Kingdom

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