Objective The main objective is risk analysis for low doses of ionising radiation using a biologically based cancer model. Important aspects are: the form of the dose-effect relationship at very low doses and the question whether it is linear, linear-quadratic or whether there is a threshold. The ultimate aim is the derivation of improved estimates of radiation risks for radiological protection.The main task for the applicant will be to continue working with the two-mutation carcinogenesis (TMC) model, to advance the model and make it applicable for other data sets and cancer in other organs, to use suitable animal data to investigate mechanistic aspects of radiological effects and to investigate suitable epidemiological data for description and model testing.The proposed research allows to consider and possibly implement new concepts such as an induction of cellular defence mechanisms and bystander effects. These important radiobiological phenomena could be included and tested within the framework of the TMC model.The applicant works in the field of low dose research since more than 8 years and is currently involved with the EU project CEC .Contract FIGH-CT-1999-00005. His range of knowledge and expertise in the field of the proposed research is interesting to be incorporated into the TMC model. Fields of science natural sciencesphysical sciencesnuclear physicsmedical and health sciencesclinical medicineoncology Programme(s) FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002) Topic(s) 2.1.3. - RTD activities of a generic nature Call for proposal Data not available Funding Scheme RGI - Research grants (individual fellowships) Coordinator NATIONAL INSTITUTE OF PUBLIC HEALTH AND ENVIRONMENT EU contribution No data Address 9,Antonie van Leeuwenhoeklaan 9 3720 BA BILTHOVEN Netherlands See on map Total cost No data
