Objective
The proposal is to develop a novel chemical system that allows the chemistry on the inside of a vesicle membrane to be coupled to a selective molecular recognition event on the outside of the membrane, but without direct physical transport of any chemical entities across the membrane. This will allow the development of a module system where the recognition units on the outside of the membrane can be varied at will and the nature of the chemical signal generated on the inside of the membrane can be amplified and tailored for a variety of different applications. A simple prototype system has been developed in the Hunter lab, and the key objectives for this proposal are
1. to develop an enzymatic system that will transduce and amplify the chemical signal generated on the inside of the vesicles
2. to explore the scope of possible external recognition head groups that will interface effectively with the transduction system. The project will provide excellent training for the applicant, who will learn and improve a wide range of skills including organic synthesis, bio-organic synthesis, membrane chemistry, spectroscopy, analysis and molecular modeling. In addition, the applicant will have the opportunity to work in a multidisciplinary group that is a leader in supramolecular chemistry and molecular recognition in the UK, and this will be particularly important for the applicant's future career. Significant breakthroughs in new areas of science are increasingly coming from a multi-disciplinary approach to research, and well-trained scientists with a background in inter-disciplinary research will be at the forefront of these developments in the future.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
S3 7HF Sheffield
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.