Objective
In skeletal and heart muscle, the signal transduction between the cell surface membrane and the contractile apparatus, called excitation-contraction coupling (ECC), is a model for calcium flux and homeostasis of unique importance. No other organs respond so dramatically to their use or inactivity by hypertrophy or atrophy. Our aim is to study the regulation and molecular basis of ECC in health and disease in man and in animal and cell models.
Our goals are:
a) to identify novel ECC proteins and characterize their interaction at the molecular level;
b) to study localization and targeting of the proteins to their respective compartments, and their interaction using cellular and animal and disease models;
c ) to functionally analyze ECC and calcium signaling with high-resolution imaging and electrophysiological techniques;
d) to study the genetics and pathophysiology of disease arising from EEC defects. Our proposal integrates a large number of state-of -the-art technologies in the fields of protein biochemistry, molecular genetics, cell biology and physiology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences molecular biology molecular genetics
- medical and health sciences basic medicine physiology pathophysiology
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
89069 ULM
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.