Objective With a prevalence of about 2%, mental retardation (MR) poses an important medical and socio-economic problem. The European MRX Consortium has been instrumental in characterizing families with non-specific X-linked MR (MRX) and cloning most of the MRX genes, with two objectives:(1) increasing the possibilities for genetic counselling for MR (X) and(2) elucidation of the neurobiological mechanisms underlying MR, to create a basis for therapeutic intervention. Using neuronal tissue cultures and genetically modified mice we will study the biological mechanisms which link MRX gene defects to deficient cognitive functioning in humans. In addition, cloning of additional MRX genes will be accelerated using highly innovative approaches. These studies will greatly enhance our understanding of the cellular basis of cognition. Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-9. - Neurosciences Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator STICHTING KATHOLIEKE UNIVERSITEIT EU contribution No data Address 10,Geert Grooteplein 10 6500 HB NIJMEGEN Netherlands See on map Links Website Opens in new window Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all CYPRUS INSTITUTE OF NEUROLOGY AND GENETICS Cyprus EU contribution No data Address International Airport Avenue, No.6 2370 NICOSIA See on map Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution No data Address c/o Faculte de Medecine, boulevard Tonnelle, 2 bis 37032 TOURS See on map Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution No data Address Rue du General Sarrail, 8 94010 CRETEIL See on map Total cost No data KAROL MARCINKOWSKI UNIVERSITY OF MEDICAL SCIENCES - ACADEMY OF MEDICINE Poland EU contribution No data Address Ul. Szpitalna, 27/30 60 572 POZNAN See on map Total cost No data KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution No data Address 49,Herestraat 49 3000 LOUVAIN / LEUVEN See on map Total cost No data MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Germany EU contribution No data Address Ihnestrasse 73 14195 BERLIN See on map Total cost No data ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCE Netherlands EU contribution No data Address Meibergdreef 33 1105 AZ AMSTERDAM See on map Total cost No data
