Objective The project is devoted to building a comprehensive model of mammalian cell-cycle regulatory network in normal and pathological states. This model will be used to make computer-aided predictions of potential anticancer pharmacological agents for key target molecules. The following main objectives will be achieved during realisation of this project.We will create a database on cell cycle specific and related genes that will include available information on micro array gene expression data, data on gene transcription and translation regulation, proteomics data, comparative genomic data, SNP and other gene diversity data as well as related clinical data. We will Develop models of the structure of genomic regulatory regions controlling gene expression of the most important genes involved in cell cycle regulation and predict new genes in genome involved in the cell cycle regulatory network. We will build a computer model of the core regulatory network of mammalian cell cycle. Analyse the structure and dynamic properties of the cell-cycle model, identify possible stationary states, investigate parametric stability of network, bifurcation analysis, identify the most critical components and parameters that can move system from one stationary state to another. We will modelling the structural and parametric changes in cell cycle regulatory networks during normal process of cell differentiation and the perturbations that are observed in different pathological situations for example deregulated cell proliferation. Identification of the components responsible for such perturbations and Identification of targets and of mechanisms how cell cycle perturbations can be minimized and/or how cancer cells can de directed into apoptosis will be done.Finally, using the most modern methods of chemoinformatics we will search for pharmacological agents that can influence the potential target molecules revealed by the modelling. We will do modelling of the prolonged effects of the influence of the proposed pharmacological agents on dynamics of cell-cycle. Integrating all knowledge collected and obtained on the previous steps into the most comprehensive knowledge databasebase on mammalian cell cycle regulatory network will be performed during realisation of this project. Programme(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Topic(s) OPEN - OPEN Call Call for proposal Data not available Funding Scheme Data not available Coordinator BIOBASE GMBH EU contribution No data Address HALCHTERSCHE STRAßE, 33 WOLFENBÜTTEL Germany See on map Total cost No data Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all Institute of Biomedical Technologies (ITB), CNR Italy EU contribution No data Address Via Fratelli Cervi 93 20090 Segrate (MI) See on map Total cost No data Russian Academy of Medical Sciences Institute of Biomedical Chemistry - IBMC RAMS Russia EU contribution No data Address Pogodinskaya str. 10 119832 Moscow See on map Total cost No data Siberian Branch of Russian Academy of Sciences Design Technological Institute of Digital Techniques Russia EU contribution No data Address Intitutskaya 6 630090 Novosibirsk See on map Total cost No data
