Objective
The aim of this proposal is to enhance the European leadership in three-dimensional (3D) electron microscopy. HT-3DEM proposes to develop an automated platform to enable high throughput screening and analysis of native protein complexes and protein crysta ls by electron microscopy. For this purpose, HT-3DEM brings together European experts in electron microscopy, 2D crystallisation, machine vision, and robotics with leading manufacturers of electron microscopes and microsystem technologies. The innovative t echnology platform will include (i) a robot for the production of 2D protein crystals, (ii) the automated preparation of 2D crystals and native protein complexes for EM analysis, (iii) automated image acquisition and sample analysis by electron microscopy and (iv) management of all data produced in the pipeline. Each of these objectives represents a substantial advance of the state of the art. The innovations generated in HT-3DEM will greatly increase the throughput in 3D electron microscopy and thus enhan ce European competitiveness in the field of structural genomics. The reduction of processing times and cost for individual samples will open new fields to the application of this versatile technology platform. These are envisaged to include, among others, health care (screening of patient materials for infective agents) and pharma industry (acceleration of rational drug design). HT-3DEM thus responds to the needs of the European Community to improve human health and to increase the competitiveness of Europ ean pharma industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine medicinal chemistry
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences computer and information sciences artificial intelligence computer vision
- natural sciences physical sciences optics microscopy electron microscopy
- natural sciences biological sciences biochemistry biomolecules lipids
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BASEL
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.