Objective The general aim of CAESAR is to produce (Q)SAR models for the prediction of the toxicity of chemical substances. These models will be designed to be used for regulatory purposes, more specifically to assist the implementation of the proposed REACH system. The project will develop predictive in silicon models for chemical toxicity. These modelling approaches will reduce the dependence on the use of animals as well as the costs associated with toxicity tests, and will have wide-ranging applications.The work will involve a robust and detailed characterisation of the most relevant endpoints as defined in EC documents relating to the requirements for REACH. Utmost attention will be paid to obtain a solid experimental basis by the use of toxicity data that have been checked for quality at all stages. At least 5 clearly defined data sets along with suitable statistical techniques will be exploited to form powerful, innovative and thoroughly validated (Q)SAR models. Models developed by each partner will be checked by at least one other partner. Each model will be characterised by its statistical uncertainty. The presence of false negative predictions will also be evaluated to reduce the risk of predicting potentially harmful compounds to be non-toxic. The applicability domain of each (Q)SAR will be described, both in terms of its boundaries and density in chemical and biological space. For each (Q)SAR, a detailed protocol will be prepared, describing the standardised models and the quality procedure adopted.The (Q)SAR models developed in this project, and their protocols, will be placed on the project's internet site to allow the widest possible free access. Further dissemination of the models will be through an international workshop at the end of the project. Exploitation will be achieved through the involvement of users and regulatory bodies. An external review committee will be formed to monitor the project progress and provide advice. Fields of science natural sciencescomputer and information sciencesinternetnatural sciencescomputer and information sciencesdatabasesnatural scienceschemical sciencesinorganic chemistrymetalloids Programme(s) FP6-POLICIES - Policy support: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) POLICIES-1.5 - Environmental assessment Call for proposal FP6-2004-SSP-4 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator ISTITUTO DI RICERCHE FARMACOLOGICHE "MARIO NEGRI" EU contribution No data Address VIA ERITREA 62 MILANO Italy See on map Links Website Opens in new window Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all BIOCHEMICS CONSULTING SAS France EU contribution No data Address Centre d'Innovation - Rue Leonard de Vinci, 16 ORLEANS See on map Links Website Opens in new window Total cost No data CENTRAL SCIENCE LABORATORY United Kingdom EU contribution No data Address Nobel House 17 Smith Square LONDON See on map Links Website Opens in new window Total cost No data KEMIJSKI INSTITUT LJUBLJANA SLOVENIJA Slovenia EU contribution No data Address Hajdrihova 19 LJUBLJANA See on map Links Website Opens in new window Total cost No data KNOWLEDGEMINER SOFTWARE FRANK LEMKE Germany EU contribution No data Address Duererstr. 40 PANKETAL See on map Links Website Opens in new window Total cost No data LIVERPOOL JOHN MOORES UNIVERSITY United Kingdom EU contribution No data Address Mount Pleasant 70, Rodney House, Rodney Street 2 LIVERPOOL See on map Links Website Opens in new window Total cost No data NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK - TNO Netherlands EU contribution No data Address Schoemakerstaat 97 DELFT See on map Total cost No data POLITECNICO DI MILANO Italy EU contribution No data Address PIAZZA LEONARDO DA VINCI 32 20133 MILANO See on map Total cost No data UFZ - UMWELTFORSCHUNGSZENTRUM LEIPZIG-HALLE GMBH. Germany EU contribution No data Address Permoser Strasse 15 LEIPZIG See on map Links Website Opens in new window Total cost No data