Objective HEVAR is a collaborative project involving four academic laboratories from four European countries (France, Switzerland, Germany, Italy) and four academic laboratories belonging to three South American countries (Argentine, Brazil, Uruguay). The overall scientific goal of HEVAR is to contribute to a better understanding of the immune biology of rotavirus infections using a novel generation of gene transfer vectors derived from herpes virus simplex type 1 (HSV-1), as a first step towards the development of innovative genetic vaccines to fight against these pathogens, which are the most common cause of severe dehydrating diarrhoea in young children of developing countries. In addition to contributing to a better understanding of the immune biology of rotavirus infection and of evaluating the feasibility of using HSV-1 vectors as anti-rotavirus vaccines, the main deliverables of HEVAR will be a set of toolboxes containing a large collection of HSV-1-based and DNA-based vectors expressing human and mouse rotavirus antigens that will be evaluated in mice, which will be rendered accessible to any academic team wishing to use them for vaccine development or fundamental research on rotaviruses.A last set of deliverables will consist in a series of scientific meetings and events required to achieve the transfer of knowledge and complex technology required to generate, produce, and evaluate, the HSV-1-based gene transfer vectors in South America, therefore improving the human capital and the technological competence of these countries. In addition, the transfer from South American partners to European teams of up-to-date knowledge on the biology of rotavirus and other endemic viruses, with high social cost in South America, will strength the awareness to-, and a better understanding of-, these neglected diseases. Fields of science medical and health sciencesmedical biotechnologygenetic engineeringgene therapymedical and health sciencesbasic medicineimmunologyimmunisationnatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health scienceshealth sciencesinfectious diseasesDNA viruses Programme(s) FP6-INCO - Specific measures in support of international cooperation: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) INCO-2004-A1.3 - Knowledge and technologies to improve control of neglected communicable diseases Call for proposal FP6-2004-INCO-DEV-3 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator UNIVERSITÉ CLAUDE BERNARD LYON 1 EU contribution No data Address 43 boulevard du 11 novembre 1918 VILLEURBANNE France See on map Links Website Opens in new window Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all FUNDAÇAO OSWALDO CRUZ Brazil EU contribution No data Address Avenida Brasil 4365 RIO DE JANEIRO See on map Links Website Opens in new window Total cost No data LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Germany EU contribution No data Address Geschwister-Scholl-Platz 1 MUENCHEN See on map Links Website Opens in new window Total cost No data UNIVERSIDAD DE LA REPÚBLICA Uruguay EU contribution No data Address 18 de Julio 1824 MONTEVIDEO See on map Links Website Opens in new window Total cost No data UNIVERSIDAD NACIONAL DE QUILMES Argentina EU contribution No data Address Roque Sáenz Peña 352 BERNAL, BUENOS AIRES See on map Links Website Opens in new window Total cost No data UNIVERSIDAD NACIONAL DEL LITORAL Argentina EU contribution No data Address Boulevard Pellegrini 2750 SANTA FE See on map Links Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI FERRARA Italy EU contribution No data Address Via Savonarola n 9 FERRARA See on map Links Website Opens in new window Total cost No data UNIVERSITÄT ZÜRICH Switzerland EU contribution No data Address Raemistrasse 71 ZURICH See on map Links Website Opens in new window Total cost No data
