Objective
Surface plasmon resonance (SPR) spectroscopy has proven its utility and versatility in many studies, with a focal point in biochemical investigations. SPR is regarded as the most sensitive method in label-free analysis. Surface plasmon resonance imaging (S PRi) improves on the single spot interrogation of a sample by imaging an area of the sample, which can consist of a diverse sample matrix. Instead of monitoring the angular shift of the reflection minimum, a fixed angle measurement near the SPR angle is performed.
A very high detection sensitivity comparable to that of fluorescence spectroscopy is often demanded in various measurements to probe low concentration binding/interactions or weak affinities. Research efforts will focus on improvement of the detect ion sensitivity by developing wave-guide SPR imaging (WSPRi) and using nanoparticles for signal enhancement. The use of WSPRi allows for the excitation of plasmon resonance with both p and s polarized light. The resulting reflectivity spectra posses a much reduced half-width which translates to a higher sensitivity in imaging mode. Nanoparticle functionalised antibodies in combination with silver staining will be applied and the protocol optimised, aiming at a signal improvement by two to three orders of magnitude compared to existing SPR imaging assays.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences condensed matter physics quasiparticles
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences physical sciences optics spectroscopy emission spectroscopy
- natural sciences physical sciences optics microscopy
- natural sciences biological sciences biochemistry biomolecules lipids
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.