Objective
The complete set of genes of the nuclear genome of Trypanosoma cruzi, the protozoan parasite that causes Chagas disease, can now be exploited in the search of new drugs to fight American trypanosomiasis.
In this context, the work plan of this fellowship b rings together the proteomic expertise and facilities of the Institute Cochin with the expertise of Dr. Mariano J. Levin in the field of T.cruzi gene structure, expression and RNA processing, in an attempt to validate protein-protein interactions involved in essential steps of the T.cruzi spliceosomal assembly as targets for novel anti-parasitic therapeutic interventions.
Accordingly, the initial goal of this proposal is to identify the complete set of proteins of the early splicing complex (E complex) and the pre-splicing complex A of the T.cruzi spliceosome, and map protein-protein interactions using yeast two hybrid techniques.
This should lead in turn,
- to build a protein- protein interaction map of the early and presplicing complexes of the pretrans-spliceosome of the parasite,
- to detect T.cruzi specific and essential interactor pairs,
- to use these protein-protein interactions as targets of screenings for RNA processing blocking compounds and
- to test their trypanomicidal effect.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-7
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.