Objective
Cerebral palsy (CP) is caused by lesions to the developing brain, and has a prevalence of 2/1000 live births. It has significant implications for participation in many areas of society (e.g. employment), and impaired hand motor function plays an important role. Research on effects of intervention is needed to optimise treatment, with the goal to improve integration of individuals with CP into society. For a complete understanding, it is necessary to study intervention effects on different levels (motor func tion, anatomical brain structure, brain activation patterns, integrity of sensory-motor circuits).
This requires a combination of techniques in a multidisciplinary setting. In children, no such study has been performed to date. We will study a group of chi ldren with congenital hemiplegic CP who will receive intensive upper limb training (Constraint Induced Movement Therapy), and assessments before and after training.
We hypothesise that
(i) intervention will lead to improved hand motor function;
(ii) interve ntion will be associated with changes in brain re-organisation; (iii) motor function and re-organisation will be associated with location/extent of lesions.
We will test these hypotheses by using modern tools for assessment of motor function in combination with new magnetic resonance imaging (MRI) techniques (including Diffusion Tensor Imaging and functional MRI), and neurophysiology tools (Transcranial Magnetic Stimulation).
The results of this study will
(i) provide new insights in mechanisms of the brain `s response to early injury and intervention later in life;
(ii) lead to better integration of individuals with CP into society;
(iii) lead to social/economic benefits on a Community level.
For the applicant, participation in this study will be an importan t step in her research career with the ultimate goal of leading an internationally competitive group with the focus on investigation of brain structure-function relationships after early brain lesions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pathology
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
- social sciences economics and business business and management employment
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.