Objective
According to WHO estimates, more than 20% of the European population will be aged 60 and above in 2020. The increase in age-associated neurological diseases such as Alzheimer's disease, Parkinson's disease and stroke will creates growing health-economic problems for European society and will have a major impact on the quality-of-life of the individual. Current treatment options for neurological diseases are limited and fail to lead to functional recovery.
Adult neural stem cells (NSCs) hold great promise for restorative therapy because of their privileged location within the central nervous system and their potential to generate new functional brain cells including neurons.
The recruitment of NSCs for repair poses multiple challenges. In the adult brain, NSCs are largely quiescent and divide only infrequently. Although their proliferation increases in e.g. injury or stroke, the number of newly generated cells appears to be insufficient to compensate for the cell loss. A better understanding of the regulation of NSC quiescence and proliferation is necessary for the development of therapeutic strategies that aim at the mobilization of NSCs for repair. In the adult hippocampus, quiescent NSCs are constantly recruited into proliferation to generate new neurons.
In the proposed project we will exploit this model system to characterize the molecular control of NSC quiescence and proliferation. Our preliminary data has identified PI3-kinase signalling as a candidate pathway in this process. Using a combinatio n of molecular and cell biology, genetics, and pharmacology, we will examine the role of PI3-kinase signalling in the control of the proliferate activity of NSCs.
In addition, we will use transcriptome and proteome analysis to identify downstream targets of PI3-kinase signalling in quiescent and proliferating NSCs. These studies will contribute to the understanding of basic NSC biology and will identify new candidate drug targets for NSC-based therapies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- medical and health sciences basic medicine neurology neurodegenerative diseases dementia alzheimer
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences basic medicine neurology stroke
- medical and health sciences basic medicine neurology neurodegenerative diseases parkinson
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-8
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MUNICH-NEUHERBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.