Sensor nanoparticles for ions and bio-molecules

Projektinformationen

SNIB

ID Finanzhilfevereinbarung: 29554

Projekt abgeschlossen

Startdatum 1 August 2006

Enddatum 31 Juli 2010

Finanziert unter

• Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Gesamtkosten € 0,00

EU-Beitrag € 1 153 287,00

Koordiniert durch

FRIEDRICH-SCHILLER-UNIVERSITAET JENA
Germany

Ziel

The task of SNIB is to develop functional nanoparticles that allow the detection of ions (e.g. sodium, potassium, chloride), biomolecules (e.g. transmitter substances, amino acids, saccharides) or drugs and their metabolites in living cells and tissues. Analyte recognition is achieved via fluorescent indicator dyes that are embedded in the matrix of the nanoparticles. Specific binding of the analytes to the fluorophore causes changes in the fluorescence properties (e.g. fluorescence intensity and lifetime).

The polymer matrix of the nanoparticle does not only provide a selective scaffold for the fluorophore, it also provides a defined microenvironment, in which the binding of the analyte and the concomitant change in fluorescence cannot be compromised by interfering biomolecules (e.g. proteins). The size of the nanoparticles can be tailored to the specific task. Molecularly imprinted analyte-sensitive nanoparticles of larger diameter (300 - 600 nm) may be embedded in tissues whereas small nanoparticles (50 - 300 nm) can be injected directly into living cells. Unlike common indicator dyes, nanoparticles do not bind to proteins or accumulate in certain cell compartments.

This fact makes nanoparticles especially suited for the detection of ions whose detection via fluorescent indicator dyes is still limited. Furthermore, molecularly imprinted nanoparticles can open new ways for the detection of biomolecules that cannot be detected presently via fluorescent indicator dyes. Fluorescent nanoparticles will also be applied in process analysis, for the monitoring of food quality, and for the detection of toxic substances and warfare agents.

Wissenschaftliches Gebiet

• natural sciences › chemical sciences › inorganic chemistry › alkali metals
• natural sciences › chemical sciences › polymer sciences
• engineering and technology › electrical engineering, electronic engineering, information engineering › electronic engineering › sensors
• engineering and technology › nanotechnology › nano-materials
• natural sciences › chemical sciences › organic chemistry › amines

Schlüsselbegriffe

• Chemosensors
• Fluorescent nanolayers
• Fluorescent nanoparticles
• Molecularly imprinted nanoparticles

Programm/Programme

• FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Thema/Themen

• MOBILITY-1.3 - Marie Curie Host Fellowships - Transfer of knowledge (TOK)

Aufforderung zur Vorschlagseinreichung

FP6-2004-MOBILITY-3
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

TOK - Marie Curie actions-Transfer of Knowledge

Koordinator

FRIEDRICH-SCHILLER-UNIVERSITAET JENA

• EU-Beitrag: Keine Daten
• Adresse: Fuerstengraben 1 ; JENA ; Deutschland
• Gesamtkosten: Keine Daten

Beteiligte (2)

UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE

Frankreich

• EU-Beitrag: Keine Daten
• Adresse: Rue Roger Couttolenc ; 60319 COMPIEGNE
• Gesamtkosten: Keine Daten

UNIVERSITY OF EAST ANGLIA

Vereinigtes Königreich

• EU-Beitrag: Keine Daten
• Adresse: University Drive ; NORWICH
• Gesamtkosten: Keine Daten