Objective A Europe-wide consortium of experimental biologists, biomathematicians, biostatisticians, computer scientists and clinical scientists will team up to approach cell death pathways in health and disease, placing particular emphasis on cancer and AIDS. The consortium will create a unique database integrating existing and accumulating knowledge on lethal signal transduction pathways leading to apoptosis or non-apoptotic (necrotic, autophagic, mitotic) cell death, perform data mining to integrate system-wide analyses on cell death (genome, epigenome, transcriptome, proteome, lipidome data), and use high-throughput methods (“omics”, CHiP-chip and genome-wide siRNA screens) for the experimental exploration of death pathways in human cell lines in vitro and in relevant disease models (in vitro in human cells and in vivo in mice and Drosophila). In addition, the consortium will establish mathematical models of lethal pathways to devise algorithms that predict apoptosis susceptibility and resistance, obtain data (genome, transcriptome, proteome, lipidome) on clinical samples (cancer cell lines, cancer tissues, serum, and blood samples) and perform biostatistical analyses on them in order to demonstrate the contribution of apoptotic process in human cancers and AIDS. Then, the consortium will integrate the knowledge into mathematical models for the optimal interpretation of clinical data, aiming at optimal diagnostic and prognostic performance as well as at the identification of possible therapeutic targets for the treatment of cancer and AIDS. Fields of science medical and health scienceshealth sciencespublic healthepidemiologymodeling of diseases spread Keywords AIDS apoptosis cancer cell death systems biology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.1.2-4 - Developing an integrated in vitro, in vivo and systems biology modelling approach to understanding apoptosis in the context of health and disease Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator KAROLINSKA INSTITUTET EU contribution € 1 473 182,39 Address Nobels Vag 5 17177 Stockholm Sweden See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Per-Olof Larsson (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (23) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 860 000,00 Address RUE DE TOLBIAC 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Audrey Laurent (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT CURIE France EU contribution € 597 697,60 Address RUE D ULM 26 75231 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Corinne Cumin (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO Italy EU contribution € 580 000,00 Address Via Portuense, 292 00149 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Administrative Contact Cinzia Bomboni (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data VIB VZW Belgium EU contribution € 530 000,00 Address SUZANNE TASSIERSTRAAT 1 9052 ZWIJNAARDE - GENT See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Research Organisations Administrative Contact Wim Goemaere (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAET ULM Participation ended Germany EU contribution € 114 846,06 Address HELMHOLTZSTRASSE 16 89081 Ulm See on map Region Baden-Württemberg Tübingen Ulm, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Frank Gleixner (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE DE LAUSANNE Switzerland EU contribution € 480 000,00 Address QUARTIER UNIL CENTRE - BATIMENT UNICENTRE 1015 LAUSANNE See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Administrative Contact Nicolas Fasel (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KRAEFTENS BEKAEMPELSE Denmark EU contribution € 470 000,00 Address STRANDBOULEVARDEN 49 2100 Koebenhavn See on map Region Danmark Hovedstaden Byen København Activity type Research Organisations Administrative Contact David Mollerup (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE France EU contribution € 389 687,20 Address Rue Laurent Fries 1 67404 Illkirch Graffenstaden See on map Region Grand Est Alsace Bas-Rhin Activity type Research Organisations Administrative Contact Katel Schaeffer (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data WEIZMANN INSTITUTE OF SCIENCE Israel EU contribution € 530 000,00 Address HERZL STREET 234 7610001 Rehovot See on map Activity type Higher or Secondary Education Establishments Administrative Contact Talia Tzahor (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TEKNOLOGIAN TUTKIMUSKESKUS VTT Finland EU contribution € 380 000,00 Address TEKNIIKANTIE 4 A 02044 VTT ESPOO See on map Activity type Research Organisations Administrative Contact Jaana Heino (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Germany EU contribution € 390 000,00 Address IM NEUENHEIMER FELD 280 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Administrative Contact Bettina Crispin (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EUROPEAN MOLECULAR BIOLOGY LABORATORY Germany EU contribution € 363 059,00 Address Meyerhofstrasse 1 69117 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Administrative Contact Keith Williamson (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TEL AVIV UNIVERSITY Israel EU contribution € 300 000,00 Address RAMAT AVIV 69978 Tel Aviv See on map Activity type Higher or Secondary Education Establishments Administrative Contact Lea Pais (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany EU contribution € 787 692,00 Address HOFGARTENSTRASSE 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Birgit Knepper-Nicolai (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH Austria EU contribution € 470 000,00 Address DR BOHRGASSE 3 1030 Wien See on map Region Ostösterreich Wien Wien Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Tanja Winkler (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SYDDANSK UNIVERSITET Denmark EU contribution € 459 700,00 Address CAMPUSVEJ 55 5230 Odense M See on map Region Danmark Syddanmark Fyn Activity type Higher or Secondary Education Establishments Administrative Contact Jens V. Kierkegaard (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ROYAL COLLEGE OF SURGEONS IN IRELAND Ireland EU contribution € 270 000,00 Address ST STEPHEN'S GREEN 123 2 Dublin See on map Region Ireland Northern and Western Border Activity type Higher or Secondary Education Establishments Administrative Contact Barry Mcgowan (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAET GRAZ Austria EU contribution € 270 004,00 Address UNIVERSITATSPLATZ 3 8010 Graz See on map Region Südösterreich Steiermark Graz Activity type Higher or Secondary Education Establishments Administrative Contact Frank Madeo (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE LYON 1 CLAUDE BERNARD France EU contribution € 300 000,00 Address BOULEVARD DU 11 NOVEMBRE 1918 NUM43 69622 Villeurbanne Cedex See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Higher or Secondary Education Establishments Administrative Contact Javier Olaiz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DELLA CAMPANIA LUIGI VANVITELLI Italy EU contribution € 269 980,00 Address VIALE ABRAMO LINCOLN 5 81100 Caserta See on map Region Sud Campania Caserta Activity type Higher or Secondary Education Establishments Administrative Contact Annunziata Valente (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDICEL OY Participation ended Finland EU contribution € 193 798,61 Address HAARTMANINKATU 8 00290 HELSINKI See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Christophe Roos (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KLINIKUM DER JOHANN WOLFGANG VON GOETHE UNIVERSITAET Germany EU contribution € 302 654,00 Address THEODOR STERN KAI 7 60596 Frankfurt Am Main See on map Region Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Kseniya Polozheyeva (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE D'AIX MARSEILLE France EU contribution € 217 699,14 Address BOULEVARD CHARLES LIVON 58 LE PHARO 13284 Marseille See on map Region Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône Activity type Higher or Secondary Education Establishments Administrative Contact Celine Damon (Ms.) Links Contact the organisation Opens in new window Total cost No data