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Mechanisms of early protective exposures on allergy development

Mechanisms of early protective exposures on allergy development

Objective

Allergy has developed into a major health concern in Europe. Allergic diseases can currently be managed effectively but not cured. The onset of allergies stars early in life and there is increasing evidence that exogenous factors affecting the incidence of these illnesses exert their effect early in life, in part even prenatally. The highly interdisciplinary EFRAIM project will prospectively investigate the main protective factors in early life influencing the development of allergies in birth cohorts conducted in allergy protective environments in five European countries. These birth cohorts have been enrolling over 1,000 children and have collected detailed information on the onset of allergic illnesses, objective measures of allergies and a vast amount of information about a number of environmental exposures. Large biobanks with a variety of biological samples have been established. In the EFRAIM project particular attention will be given to the potential role of dietary exposures, lifestyle and other environmental (e.g. microbial) exposures early in life which are causal determinants rather than triggers of the illness. The mechanisms mediating these protective exposures such as the maturation of immune responses, gut colonisation, the mucosal barrier function and the genetic and epigenetic factors interacting with the environmental exposures will be investigated. The knowledge about protective exposures early in life can be turned into the development of preventive strategies. The EFRAIM project will actively address two routes of preventive interventions in animal models and in vitro studies: the development of an allergy protective milk formula and the development of an allergy vaccine. Both approaches are based on knowledge gained in the human studies. The EFRAIM project is expected to produce ground-breaking new insights on protective agents and their mechanisms that can be used to prevent the further development of allergies.
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Coordinator

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Address

Geschwister Scholl Platz 1
80539 Muenchen

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 417 000

Administrative Contact

Erika Von Mutius (Prof.)

Participants (14)

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KARDINAL SCHWARZENBERG'SCHES KRANKENHAUS BETRIEBSGESELLSCHAFT MBH

Austria

EU Contribution

€ 147 000

PHILIPPS UNIVERSITAET MARBURG

Germany

EU Contribution

€ 307 000

UNIVERSITAT ZURICH

Switzerland

EU Contribution

€ 167 000

UNIVERSITAET ULM

Germany

EU Contribution

€ 207 000

UNIVERSITE DE FRANCHE-COMTE

France

EU Contribution

€ 167 000

UNIVERSITAET BERN

Switzerland

EU Contribution

€ 47 000

Protectimmun GmbH

Germany

EU Contribution

€ 267 000

TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY

Ireland

EU Contribution

€ 187 000

UNIVERSITAT BASEL

Switzerland

EU Contribution

€ 147 000

TECHNISCHE UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 147 000

UNIVERSITEIT UTRECHT

Netherlands

EU Contribution

€ 57 000

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

EU Contribution

€ 27 000

MEDIZINISCHE HOCHSCHULE HANNOVER

Germany

EU Contribution

€ 30 000

TERVEYDEN JA HYVINVOINNIN LAITOS

Finland

EU Contribution

€ 667 000

Project information

Grant agreement ID: 211911

Status

Closed project

  • Start date

    1 February 2008

  • End date

    31 January 2012

Funded under:

FP7-KBBE

  • Overall budget:

    € 3 915 718

  • EU contribution

    € 2 988 000

Coordinated by:

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

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