Objective Allergy has developed into a major health concern in Europe. Allergic diseases can currently be managed effectively but not cured. The onset of allergies stars early in life and there is increasing evidence that exogenous factors affecting the incidence of these illnesses exert their effect early in life, in part even prenatally. The highly interdisciplinary EFRAIM project will prospectively investigate the main protective factors in early life influencing the development of allergies in birth cohorts conducted in allergy protective environments in five European countries. These birth cohorts have been enrolling over 1,000 children and have collected detailed information on the onset of allergic illnesses, objective measures of allergies and a vast amount of information about a number of environmental exposures. Large biobanks with a variety of biological samples have been established. In the EFRAIM project particular attention will be given to the potential role of dietary exposures, lifestyle and other environmental (e.g. microbial) exposures early in life which are causal determinants rather than triggers of the illness. The mechanisms mediating these protective exposures such as the maturation of immune responses, gut colonisation, the mucosal barrier function and the genetic and epigenetic factors interacting with the environmental exposures will be investigated. The knowledge about protective exposures early in life can be turned into the development of preventive strategies. The EFRAIM project will actively address two routes of preventive interventions in animal models and in vitro studies: the development of an allergy protective milk formula and the development of an allergy vaccine. Both approaches are based on knowledge gained in the human studies. The EFRAIM project is expected to produce ground-breaking new insights on protective agents and their mechanisms that can be used to prevent the further development of allergies. Fields of science medical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesclinical medicineallergology Keywords Allergy environment immunology nutrition Programme(s) FP7-KBBE - Specific Programme "Cooperation": Food, Agriculture and Biotechnology Topic(s) KBBE-2007-2-2-06 - Impact of exogenous factors in the development of allergy Call for proposal FP7-KBBE-2007-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN EU contribution € 417 000,00 Address GESCHWISTER SCHOLL PLATZ 1 80539 Muenchen Germany See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Erika Von Mutius (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (14) Sort alphabetically Sort by EU Contribution Expand all Collapse all KARDINAL SCHWARZENBERG'SCHES KRANKENHAUS BETRIEBSGESELLSCHAFT MBH Austria EU contribution € 147 000,00 Address Kardinal Schwarzenbergstrasse 2-6 5620 SCHWARZACH See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Karl Obermaier (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PHILIPPS UNIVERSITAET MARBURG Germany EU contribution € 307 000,00 Address BIEGENSTRASSE 10 35037 Marburg See on map Region Hessen Gießen Marburg-Biedenkopf Activity type Higher or Secondary Education Establishments Administrative Contact Harald Renz (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAT ZURICH Switzerland EU contribution € 167 000,00 Address RAMISTRASSE 71 8006 Zurich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Roger Lauener (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAET ULM Germany EU contribution € 207 000,00 Address HELMHOLTZSTRASSE 16 89081 Ulm See on map Region Baden-Württemberg Tübingen Ulm, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Frank Gleixner (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE DE FRANCHE-COMTE France EU contribution € 167 000,00 Address 1 RUE CLAUDE GOUDIMEL 25000 Besancon See on map Region Bourgogne-Franche-Comté Franche-Comté Doubs Activity type Higher or Secondary Education Establishments Administrative Contact Pauline Fournier (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAET BERN Switzerland EU contribution € 47 000,00 Address HOCHSCHULSTRASSE 6 3012 Bern See on map Region Schweiz/Suisse/Svizzera Espace Mittelland Bern / Berne Activity type Higher or Secondary Education Establishments Administrative Contact Urs Frey (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Protectimmun GmbH Germany EU contribution € 267 000,00 Address Uckendorfer Strasse 237e 45886 Gelsenkirchen See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Marion Kauth (Dr.) Links Contact the organisation Opens in new window Total cost No data TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY Ireland EU contribution € 187 000,00 Address Oak Park R93 Carlow See on map Region Ireland Southern South-East Activity type Higher or Secondary Education Establishments Administrative Contact Mark Ryan (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAT BASEL Switzerland EU contribution € 147 000,00 Address PETERSPLATZ 1 4051 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Charlotte Braun-Fahrländer (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TECHNISCHE UNIVERSITAET MUENCHEN Germany EU contribution € 147 000,00 Address Arcisstrasse 21 80333 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Ulrike Ronchetti (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITEIT UTRECHT Netherlands EU contribution € 57 000,00 Address HEIDELBERGLAAN 8 3584 CS Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact Monique Hoek Van Der (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES France EU contribution € 27 000,00 Address RUE LEBLANC 25 75015 PARIS 15 See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Yves Le Ray (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDIZINISCHE HOCHSCHULE HANNOVER Germany EU contribution € 30 000,00 Address Carl-Neuberg-Strasse 1 30625 Hannover See on map Region Niedersachsen Hannover Region Hannover Activity type Higher or Secondary Education Establishments Administrative Contact Michael Born (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TERVEYDEN JA HYVINVOINNIN LAITOS Finland EU contribution € 667 000,00 Address MANNERHEIMINTIE 166 00271 Helsinki See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Research Organisations Administrative Contact Unknown Unknown Links Contact the organisation Opens in new window Website Opens in new window Total cost No data