Objective
"How is the enormous cellular complexity that characterizes the vertebrate organism arising? Cell diversification depends on the coordinated deployment of multiple programs of cell commitment. One fundamental question is how a discrete number of transcriptional programs combine to produce different cell types. This research aims to address the principles of how cellular diversity is created in the sensory nervous system. Specific objectives: #1:Defining the role of Cux1/2 transcription factors in sensory neuron subtype specification. #2: Defining the role of Cux1/2 in the establishment of specific contacts in the CNS. #3: Identifying potential interactions between Cux and other transcription factors driving diversification. Methods: We propose multidisciplinary approaches including model systems and methods such as rapid assessment of gene function in the chick, peripheral neural stem cell cultures, biochemistry, advanced mouse genetics. Significance and contribution to community: Dysfunction of sensory neurons is associated with a number of diseases lacking adequate treatment (chronic pain, irritable bowel disease, gastro oesophageal reflux disease). This is due to a lack of knowledge in the molecular and functional properties of the subpopulations of sensory neurons. Understanding the molecular mechanisms controlling sensory neurons development is necessary to understand the ontogeny of diseases and may open for new strategies for treatment. Objectives of the action: My goal is to perform research at the international top level and to develop my skills to become a good research group leader. This Marie Curie Fellowship will be highly important for my future scientific carrier. It will allow me to diversify my competence methodologically, to gain new expert knowledge in sensory biology, and to further my career in one of the best neuroscience centers in Europe"
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry
- natural sciences biological sciences genetics
- medical and health sciences medical biotechnology cells technologies stem cells
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-1-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
171 77 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.