Objective
The establishment of sensory-organ innervation is crucial for behaviour, social interactions and survival. Neuronal arborisation is dictated by signals that guide neurites to their appropriate targets in combination with the spatial distribution of the target cells. To date, most emphasis has been placed on the genetic bases of neuronal-type specification and organ formation during embryonic development and, consequently, there is a serious gap in our knowledge about the long-term dynamics of organ innervation. To advance towards this goal, we will need to elucidate whether and how neuronal activity and sensory organ architecture can modulate neural arborisation. Vertebrate sensory organs represent an excellent model to study the establishment and maintenance of organ innervation. To investigate these processes, I have chosen the zebrafish mechanosensory “lateral line” as a model system. In general, planar polarized sensory hair cells in each unit of the lateral line, called neuromast, receive innervation by two afferent neurons. Hair cells can regenerate and re-innervate very rapidly, providing a simple model of sensory neurons arborisation whose dynamics can be visualized in vivo over long periods and under normal or altered physiological conditions. To investigate the mechanisms that govern the acquisition and maintenance of hair-cell innervation, I will conduct a systematic and comprehensive study of the processes that underlie the elaboration and remodelling of sensory-neuronal architecture in the lateral-line organ. I will perform high-resolution live imaging combined with sophisticated techniques to permit spatio-temporal control of protein expression. The findings derived from these studies shall reveal the mechanisms by which animals maintain sensory abilities throughout their entire lives.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences developmental biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08003 Barcelona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.