CORDIS
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Circuit specific approaches to retinal diseases

Project information

Grant agreement ID: 223156

Status

Closed project

  • Start date

    1 January 2009

  • End date

    31 December 2011

Funded under:

FP7-HEALTH

  • Overall budget:

    € 2 979 560

  • EU contribution

    € 2 250 000

Coordinated by:

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW

Netherlands

Objective

The RETICIR project focuses on neuronal mechanisms of vision from photoreceptor level to visual cortex. Physiological knowledge of the visual system will be used to address pathophysiological neuronal mechanisms of diseases affecting vision. In the project we will identify molecular and cellular disease mechanism of retinitis pigmentosa and glaucoma, and will demonstrate restoration of vision in retinas with degenerated photoreceptors from single neuronal responses in the retina all the way to cortical visual evoked responses and behavioral assays.Blindness in man often results from dysfunction of the retina. For a number of retinal diseases, the retinal circuitry is a major part of the problem. Effective strategies for treatment of those diseases and for all attempts to restore vision, understanding of the retinal circuitries is essential. Our strategy is that understanding the structure and function of specific retinal circuits should be used to find therapies to retinal diseases, like for instance retinitis pigmentosa and glaucoma. Specific circuits can be only studied with cell type specific promoters and therefore the methodology that we will use is the combination of in vivo marked cell types with genetic interference with the function of these cells and state of the art physiological and behavioral approaches.
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Coordinator

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW

Address

Kloveniersburgwal 29 Het Trippenhuis
1011 Jv Amsterdam

Netherlands

Activity type

Other

EU Contribution

€ 481 900

Administrative Contact

Maarten Kamermans (Prof.)

Participants (5)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 228 900

CARL VON OSSIETZKY UNIVERSITAET OLDENBURG

Germany

EU Contribution

€ 461 400

Novartis Forschungsstiftung

Switzerland

EU Contribution

€ 461 400

UNIVERSITAT ZURICH

Switzerland

EU Contribution

€ 461 400

INSERM - TRANSFERT SA

France

EU Contribution

€ 155 000

Project information

Grant agreement ID: 223156

Status

Closed project

  • Start date

    1 January 2009

  • End date

    31 December 2011

Funded under:

FP7-HEALTH

  • Overall budget:

    € 2 979 560

  • EU contribution

    € 2 250 000

Coordinated by:

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW

Netherlands