Objective
Cancer associated inflammation is well known to contribute to tumour progression,and pro-inflammatory mediators, including cytokines and prostaglandins, can drive malignancy. Prostaglandins are generated from arachidonic acid by the action of cyclooxygenase (COX), and include PGE2 as a major pro-inflammatory mediator, and PGD2 that has anti-inflammatory activity. While it is well known that PGE2 promotes tumourogenesis, there is little known about the role of PGD2 in cancer. Our aim is to establish the role of PGD2 in tumour progression in vivo using a syngeneic transplantable mouse model of ovarian cancer and a two-stage skin carcinogenesis model. We also aim to investigate the role of PGD2 in modulation of cancer-associated inflammation and tumour-associated macrophage (TAM) phenotype. We will use a mouse ovarian cancer model that recapitulates the peritoneal spread of stage IV human ovarian cancer. We will evaluate the role of PGD2 and its’ receptor, DP-1, using transgenic mice and synthetic agonists/antagonists. We will also use a two-stage skin carcinogenesis model to study the role of PGD2 in carcinogen-induced inflammation-associated cancer. There is a great deal on interest in the therapeutic use of COX inhibitors in cancer, we hypothesise that the potential benefits of COX inhibitors in inflammation-associated cancer may be hampered by inhibition of protective, anti-inflammatory PGD2. Our preliminary data suggest PGD2 is indeed protective in a mouse model of stage IV ovarian cancer. These further studies will not only establish a rationale for selective inhibition of prostaglandin synthesis rather than COX in ovarian cancer but may also suggest DP-1 receptor agonists could offer a new therapeutic avenue in inflammation-associated cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75654 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.