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Content archived on 2024-06-18

Targeting nucleic acid structures by site-directed ligand discovery

Objective

Nucleic acids and nucleic acid-protein interactions play an important role in biological processes of medical importance and can be considered as attractive targets for drug design. Small molecules or peptides that interact with such targets and control their functions are of great interest. Thus there is a need for a general method for rapidly identifying such low molecular weight small molecules or peptides. The focus of this proposal is to establish a new method based on a combined fragment-based and site-directed approach that exploits the power of dynamic combinatorial chemistry (DCC). This method will be used as a general strategy to target functional nucleic acid structures and their protein complexes.

Fields of science (EuroSciVoc)

Topic(s)

Call for proposal

FP7-PEOPLE-2009-IEF
See other projects for this call

Funding Scheme

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
EU contribution
€ 172 240,80
Address
TRINITY LANE THE OLD SCHOOLS
CB2 1TN CAMBRIDGE
United Kingdom
Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data