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Targeting nucleic acid structures by site-directed ligand discovery

Obiettivo

Nucleic acids and nucleic acid-protein interactions play an important role in biological processes of medical importance and can be considered as attractive targets for drug design. Small molecules or peptides that interact with such targets and control their functions are of great interest. Thus there is a need for a general method for rapidly identifying such low molecular weight small molecules or peptides. The focus of this proposal is to establish a new method based on a combined fragment-based and site-directed approach that exploits the power of dynamic combinatorial chemistry (DCC). This method will be used as a general strategy to target functional nucleic acid structures and their protein complexes.

Campo scientifico (EuroSciVoc)

Argomento(i)

Invito a presentare proposte

FP7-PEOPLE-2009-IEF
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Meccanismo di finanziamento

MC-IEF - Intra-European Fellowships (IEF)

Coordinatore

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Contributo UE
€ 172 240,80
Indirizzo
TRINITY LANE THE OLD SCHOOLS
CB2 1TN CAMBRIDGE
Regno Unito
Regione
East of England East Anglia Cambridgeshire CC
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
Nessun dato