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Synaptic Systems: dissecting brain function in health and disease

Objective

Major disorders of the Central Nervous System (CNS) affect one in three people in the developed world, often seriously disable the affected individual, and together account for the single largest burden on the healthcare systems of the EU. Most of these disorders act at the neuronal synapse, a cellular organelle comprising in the order of 2000 proteins. Pleiotropy, cross-talk between proteins and the complexity of the underlying signalling complexes pose a significant challenge to dissecting the molecular mechanisms of disease and to design efficient drugs. SynSys assembles leading European laboratories to provide the expertise and established research platforms that uniquely enable a systems-level analysis of synaptic signalling. The consortium features a closed loop from data integration and modelling, human genetics, physiology, proteomics and the application of engineered model systems to test model predictions. The main objectives of this project are to (i) provide a qualitative and quantitative description of the protein composition and the interactome of the mammalian glutamatergic synapse that integrates known human variation in these genes, (ii) to generate quantitative dynamic models describing the main functional features of the synaptic system, (iii) to reiterate on modeling by relating model predictions to synaptic function, (iv) to identify and validate, using appropriate model systems, human vulnerability genes that may form the basis of future therapies. Only a Systems level analysis can provide the means to describe synaptic transmission from molecule to function, its dynamics in relation to physiology and, brain function and brain disorders. As such, SynSys will establish a new platform for iterative molecular analysis of synapse function and dynamic modeling, with the perspective to generate a blueprint for discovery of novel pathways and targets that enable rational strategies to design therapies for human brain disease.

Field of science

  • /medical and health sciences/basic medicine/medical genetics
  • /natural sciences/biological sciences/genetics and heredity
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics
  • /medical and health sciences/basic medicine/physiology

Call for proposal

FP7-HEALTH-2009-two-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

STICHTING VU
Address
De Boelelaan 1105
1081 HV Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 072 800
Administrative Contact
Yvonne Kops (Dr.)

Participants (17)

GENOME RESEARCH LIMITED

Participation ended

United Kingdom
EU contribution
€ 32 043,76
Address
The Gibbs Building, Euston Road 215
NW1 2BE London
Activity type
Research Organisations
Administrative Contact
Seth Grant (Prof.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 1 252 740,24
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Angela Noble (Ms.)
Klinik Max Planck Institut für Psychiatrie
Germany
EU contribution
€ 1 341 200
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nils Brose (Prof.)
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
Germany
EU contribution
€ 670 620
Address
Robert Rossle Strasse 10
13125 Berlin
Activity type
Research Organisations
Administrative Contact
Andrea Winnefeld (Ms.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 294 388,50
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Tom Ratcliff (Mr.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 532 800
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ivan Kristoffersen (Mr.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 529 200
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Oleg Shupliakov (Prof.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 468 000
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Robert Preissner (Dr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 523 200
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Mihaja Auguste (Ms.)
VIB VZW
Belgium
EU contribution
€ 520 800
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
Administrative Contact
Rik Audenaert (Mr.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 385 860
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kaisa Ainala (Ms.)
Synome Ltd
United Kingdom
EU contribution
€ 435 603
Address
Moneta Building Babraham Research Campus
CB22 3AT Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Troels Jordansen (Mr.)
Brainwave-Discovery Limited
United Kingdom
EU contribution
€ 452 400
Address
Main Street Ardshiel
FK8 3RJ Gartmore
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Wayne Davies (Prof.)
BEACTICA THERAPEUTICS AB
Sweden
EU contribution
€ 444 594
Address
Virdings Alle 2
754 50 Uppsala
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Per Källblad (Dr.)
SYNAPTOLOGICS BV
Netherlands
EU contribution
€ 445 576
Address
Achillesstraat 28 2
1008 BA Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Annemieke A. Steenbergen (Ms.)
THE BABRAHAM INSTITUTE
United Kingdom
EU contribution
€ 338 011,50
Address
Babraham Hall
CB22 3AT Cambridge
Activity type
Research Organisations
Administrative Contact
Fang Gao (Mrs.)
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

Participation ended

Netherlands
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sander Jansen (Mr.)