Study of the molecular events induced by specific functional foods with a double targeting to effectively reduce cholesterol levels

Projektinformationen

CHOLESTENOT

ID Finanzhilfevereinbarung: 251285

Projekt abgeschlossen

Startdatum 15 September 2010

Enddatum 14 September 2012

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 161 293,00

EU-Beitrag € 161 293,00

Koordiniert durch

UNIVERSIDAD AUTONOMA DE MADRID
Spain

Ziel

This proposal is focused on the development of a meat-based functional food (pâté, sausage, snacks etc.) able to effectively reduce cholesterol levels in serum by acting simultaneously at two different levels: (I) reducing endogenous cholesterol synthesis by inhibiting the hydroxymethylglutaryl-CoA reductase (the key enzyme in the cholesterol metabolism) and (II) impairing exogenous cholesterol absorption during digestion by its displacement from the dietary mixed micelles and binding of bile acids during the intestinal digestion to avoid their reabsorption. Edible mushrooms will be submitted to accelerate solvent extraction (ASE) and supercritical fluid extraction (SFE) to obtain (T1) polysaccharides (b-glucans), (T2) statin-like or other metabolites and (T3) ergosterol-derivatives concentrates. These concentrates and their mixtures (T1+T2+T3 in a meat-based food matrix) will be screened for their properties to act as (I) and (II). All samples will be submitted to in vitro digestion and absorption tests (using Caco2 cell models) to study their bioavailability and molecular mechanism of action. Responsible compounds will be identified and quantified by analytical standardized tools (HPLC-, GC-MS etc)

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › carbohydrates
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2009-IIF - Marie Curie Action: "International Incoming Fellowships"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2009-IIF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IIF - International Incoming Fellowships (IIF)

Koordinator

UNIVERSIDAD AUTONOMA DE MADRID

Kontakt Verwaltung

Ana Amigo (Ms.)

• EU-Beitrag: € 161 293,00
• Adresse: CALLE EINSTEIN 3 CIUDAD UNIV CANTOBLANCO RECTORADO ; 28049 Madrid ; Spanien
• Region: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten