Objectif Preliminary work in the Zard's group has shown that cyclopropylacyl radicals can be generated from the corresponding xanthates. These unique species do not easily undergo decarbonylation or ring opening processes. These features can be exploited because the products, cyclopropyl ketones, have been found to be exceptional substrates in organic synthesis. Additionally, control of the decarbonylation and/or ring-opening processes can be combined with the powerful nature of the xanthate transfer technology in a synergistic way to provide complex skeletal diversity. The first part of the project will not only exploit the observed reactivity pattern for cyclopropylacyl radicals but will expand significantly their chemical reactivity and scope. The second part of the project will apply these findings to the asymmetric total synthesis of the natural product (+)-Ineleganolide. Champ scientifique natural scienceschemical sciencesorganic chemistryketones Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2009-IIF - Marie Curie Action: "International Incoming Fellowships" Appel à propositions FP7-PEOPLE-2009-IIF Voir d’autres projets de cet appel Régime de financement MC-IIF - International Incoming Fellowships (IIF) Coordinateur ECOLE POLYTECHNIQUE Contribution de l’UE € 166 645,60 Adresse ROUTE DE SACLAY 91128 Palaiseau Cedex France Voir sur la carte Région Ile-de-France Ile-de-France Essonne Type d’activité Higher or Secondary Education Establishments Contact administratif Aurélie Eray (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
