Obiettivo
Preliminary work in the Zard's group has shown that cyclopropylacyl radicals can be generated from the corresponding xanthates. These unique species do not easily undergo decarbonylation or ring opening processes. These features can be exploited because the products, cyclopropyl ketones, have been found to be exceptional substrates in organic synthesis. Additionally, control of the decarbonylation and/or ring-opening processes can be combined with the powerful nature of the xanthate transfer technology in a synergistic way to provide complex skeletal diversity. The first part of the project will not only exploit the observed reactivity pattern for cyclopropylacyl radicals but will expand significantly their chemical reactivity and scope. The second part of the project will apply these findings to the asymmetric total synthesis of the natural product (+)-Ineleganolide.
Campo scientifico
Invito a presentare proposte
FP7-PEOPLE-2009-IIF
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Meccanismo di finanziamento
MC-IIF - International Incoming Fellowships (IIF)Coordinatore
91128 Palaiseau Cedex
Francia