Objective
Our main goal in this proposal is the elucidation of fundamental interaction processes between microbial systems and a living organism. This research will directly lead us to a so far missing understanding of the detailed mechanism of bacterial pathogen infection in vivo. The newly gained knowledge will be highly important for the development of antibacterial drugs against pathogen-related diseases and for the ultra-sensitive detection of pathogens using bio-sensors.
Bacteria have existed for several billion years by adapting to changes in their environment. Understanding how bacteria acquire new functions in response to environmental changes will advance our fundamental knowledge thereby enhancing our ability to design and tailor changes in biological structure. We will investigate local physical and biochemical variation in the bacterial outer membrane of live bacteria, at nanometer resolution, as bacteria interact with both abiotic and biotic surfaces. For these studies we will use Escherichia coli (E. coli) primarily because it has been well studied and the genome sequence has been determined.
Biological scanning probe microscopy (SPM) is the tool of choice for these studies because it is the only instrument that allows studying living microbial organisms in their natural environment at the nano-meter scale resolution. A broad range of scanning microscopic techniques including Force spectroscopy, Topography and recognition imaging (TREC), Kelvin probe force microscopy (KPFM), and Scanning microwave microscopy (SMM) will be utilized in these studies for looking into the dynamics of individual protein domains, local binding sites, and locations of charge centers of complex proteins at sub-nanometer, pico-Newton, and nano-Ampere resolution.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences physical sciences astronomy planetary sciences planetary geology
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics microscopy
- natural sciences physical sciences optics spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IIF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
4040 Linz
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.