Project description DEENESFRITPL Innovative tools for the analysis of the deep brain Our understanding of the aetiology and functional changes of brain diseases is restricted by the inaccessibility of the brain. To address existing technological limitations, the EU-funded DEEPER project proposes to generate tools for imaging and manipulating neuronal activity in the deep brain. The tools under development include high-efficiency molecular sensors, probes for cell monitoring, microscopes and microendoscopes that offer unprecedented resolution, sensitivity and depth of focus. DEEPER will provide insight into the molecular and cellular dysfunctions associated with specific neurological and psychiatric disorders such as schizophrenia, autism and Alzheimer's disease. Show the project objective Hide the project objective Objective While brain disorders have different etiology and stem from distinct molecular and cellular dysfunctions, due to limitation in current technology they all share an incomplete understanding of the anatomical and functional alterations occurring in hard-to-access deep regions of the brain. DEEPER aims at tackling this fundamental challenge by developing an entire new class of photonic tools for imaging and manipulating neuronal activity in the deep brain with unprecedented penetration depth, resolution, sensitivity, specificity and depth of focus. Technology development in DEEPER will be driven by medical expertise and market requirements and it will be organized in three pillars focusing on: i) novel high-efficiency molecular sensors and actuators; ii) minimally invasive probes for monitoring and perturbing large populations of cells; iii) next generation multiphoton microscopes and microendoscopes. In a fourth pillar, this technological platform will enable a number of clinically relevant experiments which will contribute to reveal the molecular and cellular dysfunctions underlying the pathogenesis of specific neurological (addiction, chronic pain, Alzheimer’s disease) and psychiatric disorders (depression, schizophrenia, and autism). By shedding new light on the pathogenesis of disorders, which dramatically touch the lives of millions, DEEPER has the potential to profoundly impact our society. Moreover, in DEEPER technologists, neuroscientists, clinical and pre-clinical experts will bring the results from laboratory research to market supported by the SMEs in the consortium and by the companies and experts in the advisory board. This will make the translation and exploitation of the DEEPER technologies fast and effective, building a value chain with strong translational appeal that will strengthen Europe’s industrial position in the biophotonics market for optical neural interfaces, microscopy, and microendoscopy. Fields of science medical and health sciencesbasic medicineneurologydementiaalzheimernatural sciencesphysical sciencesopticsmicroscopyengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsmedical and health sciencesclinical medicinepsychiatryschizophrenia Keywords Neurophotonics optogenetics photoswitchable neurotransmitters fluorescent neural activity indicators optical neural interfaces fiber photometry optrodes multiphoton microscopy microendoscopy Programme(s) H2020-EU.2.1.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT) Main Programme Topic(s) ICT-36-2020 - Disruptive photonics technologies Call for proposal H2020-ICT-2018-20 See other projects for this call Sub call H2020-ICT-2020-2 Funding Scheme RIA - Research and Innovation action Coordinator FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Net EU contribution € 1 241 237,50 Address VIA MOREGO 30 16163 Genova Italy See on map Region Nord-Ovest Liguria Genova Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 241 237,50 Participants (11) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITAT ZURICH Switzerland Net EU contribution € 615 000,00 Address RAMISTRASSE 71 8006 Zurich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 615 000,00 UNIVERSITY OF STRATHCLYDE United Kingdom Net EU contribution € 699 920,00 Address Richmond Street 16 G1 1XQ Glasgow See on map Region Scotland West Central Scotland Glasgow City Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 699 920,00 ALBERT-LUDWIGS-UNIVERSITAET FREIBURG Germany Net EU contribution € 478 125,00 Address FAHNENBERGPLATZ 79098 Freiburg See on map Region Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 478 125,00 UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF Germany Net EU contribution € 250 000,00 Address Martinistrasse 52 20251 Hamburg See on map Region Hamburg Hamburg Hamburg Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 250 000,00 UNIVERSITE DE GENEVE Switzerland Net EU contribution € 427 240,00 Address RUE DU GENERAL DUFOUR 24 1211 Geneve See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 427 240,00 USTAV PRISTROJOVE TECHNIKY AVCR VVI Czechia Net EU contribution € 402 500,00 Address KRALOVOPOLSKA 147 61264 BRNO See on map Region Česko Jihovýchod Jihomoravský kraj Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 402 500,00 SORBONNE UNIVERSITE France Net EU contribution € 402 500,00 Address 21 RUE DE L'ECOLE DE MEDECINE 75006 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 402 500,00 WEIZMANN INSTITUTE OF SCIENCE Israel Net EU contribution € 437 658,75 Address HERZL STREET 234 7610001 Rehovot See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 437 658,75 FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA Spain Net EU contribution € 438 125,00 Address CARRER BALDIRI REIXAC PLANTA 2A 10-12 08028 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 438 125,00 ATLAS NEUROENGINEERING BVBA Belgium Net EU contribution € 198 950,00 Address MARIA THERESIASTRAAT 91/0202 3000 Leuven See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 198 950,00 OPTOGENIX SRL Italy Net EU contribution € 206 250,00 Address via Barsanti c/o Istituto Italiano di Tecnologia 73010 ARNESANO See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Sud Puglia Lecce Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 206 250,00
