Project description
New roles of nischarin receptor agonists in the treatment of pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer with a five-year survival rate of less than 5 %. The goal of the EU-funded REPANCAN project is to decrease the high cost and long development time of new drugs using the drug repurposing concept for a class of nischarin receptor agonists. Previously, the nischarin receptor demonstrated tumour suppressor activity in breast cancer, and its agonists might target the PDAC-associated cell invasiveness, survival, metabolism and tumour microenvironment. The project will combine bioinformatics, molecular and cellular research approaches aiming to establish a ground for repurposing low-cost drugs with proven safety to treat one of the most lethal and understudied types of cancer.
Objective
The main objective of the REPANCAN is to integrate Jelena Grahovac, PhD at the Institute for Oncology and Radiology of Serbia, as a leader of a project that will address an urgent unmet need for new treatment strategy for patients with pancreatic ductal adenocarcinoma (PDAC). PDAC is one of the most lethal types of cancer in the world, with a 5-year survival rate of less than 5% and an increasing incidence rate. Research on PDAC is limited and progress in patient survival has not been made in the last 40 years. To circumvent the high costs and long development times for new oncological drugs, the REPANCAN project will use the drug repurposing concept and establish a novel use for a class of nischarin (NISCH) receptor agonists. NISCH receptor itself has been shown to be a tumor suppressor in breast cancer and its agonists hold promise for targeting several aspects of the PDAC pathology: cell invasiveness, survival, metabolism, and the microenvironment. To address the acute demand for novel PDAC therapy, the REPANCAN project will integrate the bioinformatic, molecular and cellular research with the retrospective patient study though 3 research objectives: 1) Examination of levels of NISCH in patient tumor samples and in vitro model systems, 2) Establishment of mechanisms by which clinically approved NISCH agonists can limit PDAC growth and 3) Retrospective analysis of effects of NISCH agonist treatment on PDAC progression in patients. To strengthen the competence of Dr Grahovac and use cutting edge technologies in REPANCAN, a secondment at Dr Peter Carmeliet’s laboratory at VIB-KU Leuven is planned. REPANCAN will establish a novel prognostic marker, novel drug target and a ground for repurposing of low-cost drugs proven to be safe in one of the most lethal and understudied types of cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine oncology prostate cancer
- medical and health sciences clinical medicine radiology
- medical and health sciences clinical medicine oncology breast cancer
- medical and health sciences basic medicine pathology
- medical and health sciences clinical medicine oncology pancreatic cancer
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
11000 Belgrade
Serbia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.