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Advancing Clinico-Genomic Trials on Cancer: Open Grid Services for Improving Medical Knowledge Discovery

Descripción del proyecto


Integrated biomedical information for better health
Harnessing grid computing to fight disease

A future in which patients receive personalised treatment based on their genetic make-up is fast becoming a reality.

But the genomic and clinical techniques that makes personalised healthcare possible has left researchers wallowing in reams of medical data. Far too often, the amount of data they have gathered surpasses their ability to analyse the information and put it to good use.

To help overcome the information overload problem, the ACGT project has successfully created a computerised system to organise such data, opening the way for the medical sector to deliver more personalised services to patients and ultimately improve health care.

By making the process of data analysis faster and more efficient, ACGT’s system permits even more rapid advances in developing treatments for a variety of diseases.

Focusing on information gathered in clinical and genomic trials involving cancer patients, the ACGT researchers developed a technical infrastructure to support the efficient sharing of such knowledge.

Drugs fine-tuned to your genes

For example, such a system would help doctors to rapidly identify what form of treatment best suits which patient, even permitting drugs to be quickly developed that are fine-tuned to their needs.

Such personalised treatment promises to give doctors a better chance of giving patients the correct medication for their condition, as well as developing treatment plans in such a way that drug side effects and other complications are minimised.

Sharing and analysing data on the grid

The backbone of the infrastructure is grid computing, which harnesses the resources of multiple, dispersed computers to gather, analyse and share data.

The project’s biomedical grid infrastructure specifically allows doctors to identify cancer profiles and best treatments rapidly, although it could be used for any disease, or for research and trials.

In addition to creating the grid infrastructure, the ACGT team also developed new methods for cross-referencing medical terms and their biological contexts. They also created common standards for storing medical research information at each level of investigation.

In doing so, they addressed issues related to data sharing, including the legal and regulatory aspects.

Tested in clinical trials

Their system allows doctors to compare accurately the results of different clinical trials and lets researchers more rapidly search for information from multiple sources.

The project partners are currently using the system in clinical trials involving patients suffering from breast cancer and paediatric nephroblastoma, a rare kind of kidney cancer that affects children and is also known as Wilms’ tumour.

Their goal is to improve further upon the results obtained so far from the combination of clinical and genetic information, which in the case of treating paediatric nephroblastoma has resulted in a success rate of up to 85%.

Convocatoria de propuestas

FP6-2004-IST-4
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Régimen de financiación

IP - Integrated Project

Coordinador

GEIE ERCIM
Dirección
Route Des Lucioles 2004 Sophia Antipolis
06410 Biot
Francia
Tipo de actividad
Other
Aportación de la UE
€ 665 267

Participantes (27)

ASSOCIATION HOSPITALIERE DE BRUXELLES - CENTRE HOSPITALIER UNIVERSITAIRE BORDET - ASSOCIATION DE DROIT PUBLIC ASBL
Bélgica
Aportación de la UE
€ 556 316
Dirección
Rue Heger Bordet 1
1000 Bruxelles
Tipo de actividad
Other
UNIVERSITE DE NAMUR ASBL
Bélgica
Aportación de la UE
€ 280 476
Dirección
Rue De Bruxelles 61
5000 Namur
Tipo de actividad
Higher or Secondary Education Establishments
SIB SWISS INSTITUTE OF BIOINFORMATICS
Suiza
Aportación de la UE
€ 448 921
Dirección
Rue Michel Servet 1 Cmu
1206 Geneve
Tipo de actividad
Research Organisations
GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER
Alemania
Aportación de la UE
€ 287 578
Dirección
Welfengarten 1
30167 Hannover
Tipo de actividad
Higher or Secondary Education Establishments
UNIVERSITAT DES SAARLANDES
Alemania
Aportación de la UE
€ 731 334
Dirección
Campus
66123 Saarbrucken
Tipo de actividad
Higher or Secondary Education Establishments
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Alemania
Aportación de la UE
€ 941 128
Dirección
Hansastrasse 27C
80686 Munchen
Tipo de actividad
Research Organisations
UNIVERSITAET HAMBURG
Alemania
Aportación de la UE
€ 243 613
Dirección
Mittelweg 177
20148 Hamburg
Tipo de actividad
Higher or Secondary Education Establishments
UNIVERSIDAD DE MALAGA
España
Aportación de la UE
€ 391 379
Dirección
Avda Cervantes, Num. 2
29016 Malaga
Tipo de actividad
Higher or Secondary Education Establishments
UNIVERSIDAD POLITECNICA DE MADRID
España
Aportación de la UE
€ 593 792
Dirección
Calle Ramiro De Maeztu 7 Edificio Rectorado
28040 Madrid
Tipo de actividad
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET EN AUTOMATIQUE
Francia
Aportación de la UE
€ 364 097
Dirección
Domaine De Voluceau
78153 Le Chesnay
HEALTHGRID
Francia
Aportación de la UE
€ 342 774
Dirección
Rue Charles De Montesquieu 36
63430 Pont Du Chateau
Tipo de actividad
Other
IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece
Aportación de la UE
€ 979 701
Dirección
N Plastira Str 100
70013 Irakleio
Tipo de actividad
Research Organisations
INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS
Greece
Aportación de la UE
€ 463 152
Dirección
Patission Str. 42
10682 Athina
Tipo de actividad
Research Organisations
A. PERSIDIS & SIA OE
Greece
Aportación de la UE
€ 441 149
Dirección
Rodopoleos Street 34
167 77 Athina
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PANEPISTIMIO KRITIS
Greece
Aportación de la UE
€ 201 778
Dirección
University Campus Gallos
74100 Rethimno
Tipo de actividad
Higher or Secondary Education Establishments
ISTITUTO EUROPEO DI ONCOLOGIA SRL
Italia
Aportación de la UE
€ 243 008
Dirección
Via Filodrammatici 10
20121 Milano
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HOKKAIDO UNIVERSITY
Japón
Aportación de la UE
€ 0
Dirección
Kita 8 Nishi 5 Kita Ku
060 0808 Sapporo
Tipo de actividad
Higher or Secondary Education Establishments
UNIVERSITEIT VAN AMSTERDAM
Países Bajos
Aportación de la UE
€ 518 163
Dirección
Spui 21
1012WX Amsterdam
Tipo de actividad
Higher or Secondary Education Establishments
PHILIPS ELECTRONICS NEDERLAND BV
Países Bajos
Aportación de la UE
€ 935 328
Dirección
High Tech Campus 52
5656 AG Eindhoven
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTYTUT CHEMII BIOORGANICZNEJ POLSKIEJ AKADEMII NAUK
Polonia
Aportación de la UE
€ 597 219
Dirección
Noskowskiego 12-14
61 704 Poznan
Tipo de actividad
Research Organisations
SIVECO ROMANIA SA
Rumanía
Aportación de la UE
€ 278 195
Dirección
Soseaua Bucuresti-ploiesti 73-81 Complex Victoria Park Corp Cladire C4 Sector 1
013685 Bucuresti
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MAX IV Laboratory, Lund University
Suecia
Aportación de la UE
€ 471 279
Dirección
Paradisgatan 5C
22100 Lund
Tipo de actividad
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Aportación de la UE
€ 458 899
Dirección
Wellington Square University Offices
OX1 2JD Oxford
Tipo de actividad
Higher or Secondary Education Establishments
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Francia
Aportación de la UE
€ 0
Dirección
Rue Michel Ange 3
75794 Paris
Tipo de actividad
Other
INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE
Francia
Aportación de la UE
€ 0
Dirección
Domaine De Voluceau Rocquencourt
78153 Le Chesnay Cedex
Tipo de actividad
Research Organisations
INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE RENNES
Francia
Aportación de la UE
€ 0
Dirección
Avenue Des Buttes De Coesmes 20
35708 Rennes Cedex 7
Tipo de actividad
Higher or Secondary Education Establishments
UNIVERSITE DE RENNES I
Francia
Aportación de la UE
€ 0
Dirección
Rue Du Thabor 2
35065 Rennes Cedex
Tipo de actividad
Higher or Secondary Education Establishments