Objective
Imaging of ultra-fast, time-correlated, molecular processes in physics and the life-sciences is placing increased demands on camera technology. A new detection paradigm is necessary whereby a solid-state sensor array of pixels sensitive to a single photon is assembled. Pixels composed of detectors called Single Photon Avalanche Diodes (SPADs) will be integrated for the first time in an advanced, deep-submicron CMOS process. Large arrays of SPADs interfacing to networks of parallel digital processing units on the same chip will provide record levels of timing accuracy, sensitivity and speed. The MEGAFRAME 128x128 pixel prototype will be capable of a sustained 1,000,000 frames per second with 50 picosec time uncertainty. This will re-establish European excellence in the field of ultra-high speed video capture.
To access and process the extremely high data rates generated by the pixel array, novel system architectures must be developed. Another essential advance is a highly reproducible optical concentrator array to reclaim the fill-factor lost to pixel-level infrastructure.
The new imaging system will be evaluated using emerging time-correlated methods such as Fluorescence Lifetime Imaging Microscopy and Correlation Spectroscopy, Forster Resonance Energy Transfer, and Voltage-Sensitive Dye imaging. Resolutions and frame rates at least ten times higher than today's solutions will be achieved. Mechanisms such as calcium signalling will be monitored on single cells at 1microsec steps for the first time. Future advances in proteomics, systems biology and drug discovery are dependent on such improved understanding of intra-cellular processes.
Major contributions to multi-processing architecture, flow-control engineering and fast phenomena observation are also expected. The consortium is a unique combination of imaging technology innovators, a leading European semiconductor manufacturer and a diverse end-user community from the life-sciences, physics and chemistry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences physical sciences optics microscopy fluorescence lifetime imaging
- natural sciences physical sciences electromagnetism and electronics semiconductivity
- natural sciences physical sciences theoretical physics particle physics photons
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1015 LAUSANNE
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.