FuturEnzyme proposes an integrated solution that, starting with a clear knowledge about the manufacturers' needs, specifications and priorities and the inventory of the detergent, textiles and cosmetic benchmark, allow a targeted search for the best enzymes using big biodata mining, disruptive machine learning, activity-based bio-prospecting, protein engineering, nano-biotechnology, upscale fermentation, and downstream processing systems. Then, analyzing technology, market, consumer, and socio-economic demands, and assessing safety, risk, and life-cycle analysis during the technology and product development in an iterative process, will ensure that the results will be effective and relevant. These activities constitute the FuturEnzyme WorkPlan, that also includes a strong dissemination, communication and exploitation strategy. The expected results of the project include 2 web-based resources to screen the target enzymes, 1,000 microbial enzymes with manufacturers’ requirements (180 validated, 18 to outlast the product conditions), 3 innovative consumer products at defined scales, and dissemination, communication and exploitation actions. Overall, main activities performed included an exhaustive compilation of the manufacturers' requirements, based on which a number of protocols were implemented to screen a large diversity of bio-resources from at least 293 different locations and more than 1 billion public sequences. As a result, we retrieved 1,612 new enzymes: 678 being successfully produced, 368 validated, and 27 prioritized. The inventory of the benchmarks, LCA data, preliminary analysis of consumers’ behavior and requirements for the pre-industrial fermentation and validation tests was completed, collected and shared. Communication and dissemination, data management and exploitation plans, and a plan to collaborate with other EU projects funded were implemented. Main future activities include strengthening our collaboration with the other funded projects, performing new rounds of refine enzyme bio-prospecting, engineering and production (already ongoing), producing appropriate amounts of priority enzymes to do the first pre-industrial validations, completing the impact assessment of the LCA methodology and continuing dissemination and communication actions in close connection to exploitation actions.