A Cross-Disciplinary Alliance to Identify, PREdict and prePARe for Emerging Vector-Borne Diseases

Información del proyecto

PREPARE4VBD

Identificador del acuerdo de subvención: 101000365

DOI

10.3030/101000365

Proyecto cerrado

Fecha de la firma de la CE 5 Mayo 2021

Fecha de inicio 1 Septiembre 2021

Fecha de finalización 31 Agosto 2025

Financiado con arreglo a

• SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy

Coste total

€ 6 048 271,25

Aportación de la UE

€ 6 048 271,25

Coordinado por

KOBENHAVNS UNIVERSITET
Denmark

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (10)

Summer school training module in WP3 developed diagnostics and detection tools

Report describing the Summer school training module in WP3 developed diagnostics and detection tools

Collected bird ticks/samples from three sites made available for holo-genomic analysis

Report describing the colloection of bird tickssamples from three sites made available for hologenomic analysis

Plan for Dissemination, Exploitation and Communication

Plan for Dissemination Exploitation and Communication

Provide training for summer school module on modelling
Report on communication, exploitation and dissemination activities (2)

Report on communication, exploitation and dissemination activities

Hologenomic datasets from tick vectors in Africa generated, curated and published in a sequence repository with open access

Report describing the process of generating, curating and publishing Hologenomic datasets from tick vectors in Africa

Maps of future risk scenarios for fasciolosis available on web-site
Summer School training material on tools for Molecular Diagnostics and Bioinformatics

Report describing Summer School training material on tools for Molecular Diagnostics and Bioinformatics

Report on communication, exploitation and dissemination activities (1)

Report on communication, exploitation and dissemination activities

30 cattle genomes sequenced, annotated and placed in open data repository

Report describing the process of sequencing and annotating 30 cattle genomes, and placing these in an open data repository

Websites, patent fillings, videos etc. (4)

Three regional stakeholder engagement workshops
Coordinate 1st Summer school (Models4VBDs - Geospatial Modelling) to be held in South Africa

Coordinate 1st Summer school Models4VBDs Geospatial Modelling to be held in South Africa

Visual identity and project website for PREPARE4VBD established
Coordinate 2nd Summer school (Tools4VBDs - Molecular Detection tool) to be held in Kenya

Coordinate 2nd Summer school (Tools4VBDs – Molecular Detection tool) to be held in Kenya

Demonstrators, pilots, prototypes (1)

Pen-side automated mini-FLOTAC system to diagnose snail-borne infections in cattle

Penside automated miniFLOTAC system to diagnose snailborne infections in cattle

Publicaciones

Peer reviewed articles (20)

Climate change could fuel urinary schistosomiasis transmission in Africa and Europe

Autores: Tiem van der Deure, Tim Maes, Tine Huyse, Anna‐Sofie Stensgaard
Publicado en: Global Change Biology, Edición 30, 2024, ISSN 1354-1013
Editor: Blackwell Publishing Inc.
DOI: 10.1111/gcb.17434

Tissue-specific localization of tick-borne pathogens in ticks collected from camels in Kenya: insights into vector competence

Autores: Rua Khogali, Armanda Bastos, Joel L. Bargul, Dennis Getange, James Kabii, Daniel Masiga, Jandouwe Villinger
Publicado en: Frontiers in Cellular and Infection Microbiology, Edición 14, 2024, ISSN 2235-2988
Editor: Frontiers Media S. A.
DOI: 10.3389/fcimb.2024.1382228

<i>Coxiella burnetii</i> serostatus in dromedary camels (<i>Camelus dromedarius</i>) is associated with the presence of <i>C. burnetii</i> DNA in attached ticks in Laikipia County, Kenya

Autores: Tess Rooney, Eric M. Fèvre, Jandouwe Villinger, Maris Brenn‐White, Charles O. Cummings, Daniel Chai, Joseph Kamau, Alice Kiyong'a, Dennis Getange, Dickens O. Ochieng, Velma Kivali, Dawn Zimmerman, Marieke Rosenbaum, Felicia B. Nutter, Sharon L. Deem
Publicado en: Zoonoses and Public Health, Edición 71, 2024, Página(s) 503-514, ISSN 1863-1959
Editor: Blackwell-Wiss.-Verl
DOI: 10.1111/zph.13127

Susceptibility of lymnaeid snails to <i>Fasciola hepatica</i> and <i>Fasciola gigantica</i> (Digenea: Fasciolidae): a systematic review and meta-analysis

Autores: Philile Ignecious Ngcamphalala, Ignore Nyagura, Mokgadi Pulane Malatji, Samson Mukaratirwa
Publicado en: PeerJ, Edición 13, 2025, Página(s) e18976, ISSN 2167-8359
Editor: PeerJ
DOI: 10.7717/peerj.18976

Prevalence, Distribution and Risk Factors for Trematode Infections in Domesticated Ruminants in the Lake Victoria and Southern Highland Ecological Zones of Tanzania: A Cross-Sectional Study

Autores: Godlisten Shedrack Materu, Jahashi Nzalawahe, Mita Eva Sengupta, Anna-Sofie Stensgaard, Abdul Katakweba, Birgitte J. Vennervald, Safari Kinung’hi
Publicado en: Veterinary Sciences, Edición 11, 2025, Página(s) 595, ISSN 2306-7381
Editor: MDPI AG
DOI: 10.3390/vetsci11120595

Potential Hybridization of Fasciola hepatica and F. gigantica in Africa — A Scoping Review

Autores: Nukeri , S , Malatji , M P , Sengupta , M E , Vennervald , B J , Stensgaard , A-S , Chaisi , M & Mukaratirwa , S
Publicado en: Pathogens, Edición Vol 11, 2022, ISSN 2076-0817
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens11111303

Resistance of zebu cattle (Bos indicus) to colonization by major ruminant hoof pathogens

Autores: Peter Kuhnert, Nadia Loosli, Isabelle Brodard, Dorothea Lindtke, Joerg Jores
Publicado en: Veterinary Microbiology, Edición 296, 2024, Página(s) 110184, ISSN 0378-1135
Editor: Elsevier BV
DOI: 10.1016/j.vetmic.2024.110184

Occurrence of Fasciola (Digenea: Fasciolidae) Species in Livestock, Wildlife and Humans, and the Geographical Distribution of Their Intermediate Hosts in South Africa—A Scoping Review

Autores: Ignore Nyagura, Mokgadi Pulane Malatji, and Samson Mukaratirwa
Publicado en: Frontiers in Veterinary Science, 2022, ISSN 2297-1769
Editor: Frontiers
DOI: 10.3389/fvets.2022.935428

A dedicated deep learning workflow for automatic Fasciola hepatica and Calicophoron daubneyi egg detection using the Kubic FLOTAC microscope

Autores: Salvatore Capuozzo, Maria Paola Maurelli, Stefano Marrone, Biase Celano, Giuseppe Martone, Paola Vitiello, Ines Hammami, Antonio Bosco, Lavinia Ciuca, Giuseppe Cringoli, Carlo Sansone, Laura Rinaldi
Publicado en: International Journal for Parasitology, 2025, ISSN 0020-7519
Editor: Elsevier BV
DOI: 10.1016/j.ijpara.2025.08.007

Effects of temperature on the life history traits of intermediate host snails of fascioliasis: A systematic review

Autores: Agrippa Dube, Chester Kalinda, Tawanda Manyangadze, Tafadzwa Mindu, Moses John Chimbari
Publicado en: PLOS Neglected Tropical Diseases, Edición 17, 2023, Página(s) e0011812, ISSN 1935-2735
Editor: Public Library of Science
DOI: 10.1371/journal.pntd.0011812

Environmental DNA in human and veterinary parasitology - Current applications and future prospects for monitoring and control

Autores: M.E. Sengupta, C. Lynggaard, S. Mukaratirwa, B.J. Vennervald, A.S. Stensgaard
Publicado en: Food and Waterborne Parasitology, 2022, ISSN 2405-6766
Editor: Elsevier
DOI: 10.1016/j.fawpar.2022.e00183

Temperature impacts the bovine ex vivo immune response towards Mycoplasmopsis bovis

Autores: Thomas Démoulins, Thatcha Yimthin, Dorothea Lindtke, Lukas Eggerschwiler, Raphael Siegenthaler, Fabien Labroussaa, Joerg Jores
Publicado en: Veterinary Research, Edición 55, 2024, ISSN 1297-9716
Editor: BioMed Central Ltd
DOI: 10.1186/s13567-024-01272-3

Infection Rates of Fasciola Intermediate Host Snail Species and Their Distribution in Africa: A Systematic Review and Meta-Analysis

Autores: Mpumelelo Ian Hadebe, Tawanda Manyangadze, Chester Kalinda, Tafadzwa Mindu, Moses John Chimbari
Publicado en: Tropical Medicine and Infectious Disease, Edición 8, 2023, Página(s) 467, ISSN 2414-6366
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/tropicalmed8100467

Exploring the microbiomes of camel ticks to infer vector competence: insights from tissue-level symbiont-pathogen relationships

Autores: Rua Khogali, Armanda Bastos, Dennis Getange, Joel L. Bargul, Shewit Kalayou, Nehemiah Ongeso, Joost Theo Petra Verhoeven, James Kabii, John Ngiela, Daniel Masiga, Jandouwe Villinger
Publicado en: Scientific Reports, Edición 15, 2025, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-024-81313-1

Quantitative modelling for dengue and Aedes mosquitoes in Africa: A systematic review of current approaches and future directions for Early Warning System development

Autores: Lembris Laanyuni Njotto, Wilfred Senyoni, Ottmar Cronie, Michael Alifrangis, Anna-Sofie Stensgaard
Publicado en: PLOS Neglected Tropical Diseases, Edición 18, 2024, Página(s) e0012679, ISSN 1935-2735
Editor: Public Library of Science (PLoS)
DOI: 10.1371/journal.pntd.0012679

Factors contributing to the abundance and spatial distribution of the invasive intermediate host snail (Pseudosuccinea columella) in uMgungundlovu district, KwaZulu-Natal, South Africa

Autores: Mpumelelo Ian Hadebe, Tawanda Manyangadze, Chester Kalinda, Moses John Chimbari
Publicado en: BMC Veterinary Research, Edición 21, 2025, ISSN 1746-6148
Editor: BioMed Central
DOI: 10.1186/s12917-025-04703-1

Comparison of Mini-FLOTAC, Flukefinder® and sedimentation techniques for detection and quantification of Fasciola hepatica and Calicophoron daubneyi eggs using spiked and naturally infected bovine faecal samples

Autores: Antonio Bosco, Lavinia Ciuca, Maria Paola Maurelli, Paola Vitiello, Giuseppe Cringoli, Joaquin M. Prada, Laura Rinaldi
Publicado en: Parasites &amp; Vectors, Edición 16, 2023, ISSN 1756-3305
Editor: BioMed Central
DOI: 10.1186/s13071-023-05890-2

Meta-analysis and systematic review of the prevalence and risk factors of animal fascioliasis in Eastern and Southern Africa between 2000 and 2023

Autores: Stellah Nambuya, Chester Kalinda, Patrick Vudriko, Moses Adriko, Million Phiri, Tafadzwa Mindu, David Wagaba, Lawrence Mugisha
Publicado en: Preventive Veterinary Medicine, Edición 239, 2025, Página(s) 106490, ISSN 0167-5877
Editor: Elsevier BV
DOI: 10.1016/j.prevetmed.2025.106490

Comparison of test performance of a conventional PCR and two field-friendly tests to detect Coxiella burnetii DNA in ticks using Bayesian latent class analysis

Autores: Maureen W. Kamau, Carmel Witte, Wynand Goosen, Mathew Mutinda, Jandouwe Villinger, Dennis Getange, Rua Khogali, Michael E. von Fricken, Eric Maurice Fèvre, Dawn Zimmerman, Yvonne-Marie Linton, Michele Miller
Publicado en: Frontiers in Veterinary Science, Edición 11, 2024, ISSN 2297-1769
Editor: Frontiers Media SA
DOI: 10.3389/fvets.2024.1396714

Infection rates of Fasciola spp. in cattle slaughtered at 13 abattoirs in six of nine provinces of South Africa

Autores: Sophy Nukeri, Mokgadi Pulane Malatji, Msawenkosi I. Sithole, Philile I. Ngcamphalala, Ignore Nyagura, Danisile Tembe, Innocent Siyanda Ndlovu, Mamohale Chaisi, Samson Mukaratirwa
Publicado en: Food and Waterborne Parasitology, Edición 39, 2025, Página(s) e00260, ISSN 2405-6766
Editor: Elsevier BV
DOI: 10.1016/j.fawpar.2025.e00260

Conference proceedings (10)

Dynamics of Fasciola hepatica and vector snail populations after an extreme summer drought event in Denmark.

Autores: Mita Eva Sengupta, Leah Lourenço, Nao Takeuchi-Storm, Stig Milan Thamsborg and Anna-Sofie Stensgaard
Publicado en: Annals of Parasitology 70(1), Edición EMOP 2024 Abstract Book, 2024, Página(s) 78, ISSN 2300-6706
Editor: The Polish Parasitological Society

Application of environmental DNA-based monitoring of vector snails and liver fluke transmission across different field settings along a latitudinal gradient from Denmark to South Africa.

Autores: Sengupta, ME., Malatji, MP., Ngcamphalala, PI., Mukaratirwa, S, Ciuca, L., Maurelli, MP., Bosco, A., Rinaldi, L., Materu, G, Kinunghi, S., Adriko, M., Mugisha, L., and Stensgaard, A-S.
Publicado en: Annals of Parasitology 70(1), Edición EMOP 2024 Abstract Book, 2024, Página(s) 78, ISSN 2300-6706
Editor: The Polish Parasitological Society

Insights into diagnosis of liver and rumen flukes in cattle within the PREPARE4VBD EU project

Autores: Maurelli MP, Bosco A, Ciuca L, Vitiello P, Cringoli G, Rinaldi L
Publicado en: 76th Sisvet Congress (21-23 June 2023), 2023
Editor: n/a

Investigating the impact of heat stress on Fasciola intermediate host snail immune defenses and life history traits across a latitudinal gradient (Denmark, Italy, Uganda, Tanzania and South Africa).

Autores: J. Upfold , ME. Sengupta , G. Materu, S. Kinunghi, C. Kalinda, A. Dube, T. Manyangadze, M. Chimbari, S. Mukaratirwa, M. Adriko, L. Mugisha, L. Ciuca, L. Rinaldi, and A-S. Stensgaard.
Publicado en: Annals of Parasitology 70(1), Edición EMOP 2024 Abstract Book, 2024, Página(s) 78, ISSN 2300-6706
Editor: The Polish Parasitological Society

8th European Veterinary Immunology Workshop: Bos taurus and Bos indicus cattle exhibit compelling different immune responses towards vector-borne viruses

Autores: Démoulins T, Yimthin T, Lindtke D, Eggerschwiler L, Siegenthaler R, Wagner T, Kuhnert P, Gross JJ, Jores J
Publicado en: 2024
Editor: n/a

A citizen-science-based approach to mosquito monitoring - experiences from a car-netting project in Denmark.

Autores: Sengupta, ME, Svenningesen, CS, Toettrup, A., Thorhauge-Thejl, E., and Stensgaard, A-S.
Publicado en: Annals of Parasitology 70(1), Edición EMOP 2024 Abstract Book, 2024, Página(s) 78, ISSN 2300-6706
Editor: Polish Parasitological Society

PREPARE4VBD: Snail borne infections in cattle in southern Italy -new insights into the biology and diagnosis of liver flukes.

Autores: Ciuca L, Hammami I, Maurelli MP, Bosco A, Vitiello P, Rinaldi L.
Publicado en: 25th International Congress of the Mediterranean Federation for Health and Production of Ruminants, Edición Proceedings, 2023, Página(s) 31-32, ISSN 2421-4558
Editor: Ruminantia

Fasciola hepatica and Lymnaeidae host snails in southern Italy.

Autores: Maurelli MP, Ciuca L, Hammami I, Vitiello P, Bosco A, Rinaldi L.
Publicado en: Annals of Parasitology 70(1), Edición EMOP 2024 Abstract Book, 2024, Página(s) 78, ISSN 2300-6706
Editor: The Polish Parasitological Society

Babesia infections in dogs and wild canids: where do we stand today?

Autores: Ciuca L, Oliva G, Gizzarelli M, Foglia Manzillo V, Rinaldi L, Maurelli MP
Publicado en: Proceedings of the XXXIII Congress of the Italian Society of Parasitology (SoIPa), Edición 33rd National congress of Italian Society of Parasitology, 2024, Página(s) 86, ISBN 978-88-943575-1-6
Editor: Italian Society of Parasitology (SoIPa)

Investigation of Ixodes ricinus tick infections and associated microbiome composition across a variety of human-impacted landscapes in two macro-climatic zones.

Autores: Sengupta ME, Verhoeven, J.T.P., Maurelli, M.P., Ciuca, L., Bosco, A., Rinaldi, L., Hansen, A.J. and Stensgaard, A-S
Publicado en: Annals of Parasitology 70(1), Edición EMOP 2024 Abstract Book, 2024, Página(s) 78, ISSN 2300-6706
Editor: The Polish Parasitological Society

Other (8)

21st International Congress for Tropical Medicine and Malaria: “Biogeography of freshwater snails (Mollusca: Gastropoda) in various agro-ecological zones across six provinces of South Africa” (Poster)

Autores: University of Kwazu-Natal
Publicado en: 2024
Editor: n/a

University of Kwazulu-Natal Post Graduate Seminar Series (virtual, online): Characterisation of tick-borne infections in cattle: use of environmental DNA, ticks and mosquito vectors for surveillance of tick-borne pathogens in Kenya (Oral presentation)

Autores: University of Kwazulu-Natal
Publicado en: 2024
Editor: n/a

Snail hosts and fluke infections in cattle: new parasitological findings from Southern Italy, WAAVP Congress

Autores: Lavinia Ciuca, Maria Paola Maurelli, Ines Hammami, Antonio Bosco, Paola Vitiello, Mita Eva Sengupta, Anna-Sofie Stensgaard, Laura Rinaldi
Publicado en: 2025
Editor: n/a

Measurements and Applications in Veterinary and Animal Sciences (MeAVeAS): Innovative technologies for diagnosis of intestinal parasites in animals and humans. (Oral Presentation)

Autores: UNINA
Publicado en: 2025
Editor: N/A

14th International Veterinary Immunology Symposium (IVIS2025): Bos taurus and Bos indicus cattle exhibit compelling different immune responses towards vector-borne viruses

Autores: Démoulins T, Yimthin Y, Zhang J, Lindtke D, Eggerschwiler L, Siegenthaler R, Kuhnert P, Gross JD , Jores J,
Publicado en: 2025
Editor: n/a

11th Ticks and Tick-Borne Pathogen Conference: “Characterisation of tick-borne infections in cattle: Use of direct PCR for surveillance of tickborne pathogens” (Poster)

Autores: icipe
Publicado en: 2024
Editor: n/a

11th Ticks and Tick-Borne Pathogen Conference: “Tick-borne pathogen distribution in tick tissues collected from dromedary camels in Kenya: Predicting vector competence”. (Oral presentation)

Autores: icipe
Publicado en: 2024
Editor: n/a

Biogeography of freshwater snails (Mollusca: Gastropoda) in variousagro-ecological zones across six provinces of South Africa

Autores: Mokgadi P. Malatji, Philile I. Ngcamphalala, Ignore Nyagura, Sophy Nukeri,
Publicado en: 2024
Editor: International Federation for Tropical Medicine