Saturated bioisosteres of benzene and their application in drug design

Objective

More than 500 of all existing drugs are phenyl-containing organic molecules. During the recent years, however, pharmaceutical companies struggle to deliver novel drugs to the market, because of the lack of innovative practical approaches towards novel drug-like “chemical space.” In this project, we will address this issue by developing novel saturated bioisosteres for ortho- and meta-substituted benzenes, and incorporate them into several known drugs (intiinflamatory Aceclofenac, antiviral Tipranavir, antihypertensive Oxprenolol, etc) to provide novel patent-free analogues with improved physico-chemical and biological properties.

Field of science

• /medical and health sciences/basic medicine/medicinal chemistry

Programme(s)

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)

Topic(s)

• ERC-2020-COG - ERC CONSOLIDATOR GRANTS

Call for proposal

ERC-2020-COG
See other projects for this call

Funding Scheme

ERC-COG - Consolidator Grant

Host institution

ENAMINE LIMITED LIABILITY COMPANY,RESEARCH AND PRODUCTION ENTERPRISE

Address

78 Chervonotkatska Str.
02094 Kyiv
Ukraine

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

EU contribution

€ 1 997 500

Beneficiaries (1)

ENAMINE LIMITED LIABILITY COMPANY,RESEARCH AND PRODUCTION ENTERPRISE

Ukraine

EU contribution

€ 1 997 500

Address

78 Chervonotkatska Str.
02094 Kyiv

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)