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Saturated bioisosteres of benzene and their application in drug design

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Unexpected Isomerization of Oxetane-Carboxylic Acids

Author(s): Bohdan Chalyk, Anastasiia Grynyova, Kateryna Filimonova, Tymofii V. Rudenko, Dmitry Dibchak, Pavel K. Mykhailiuk
Published in: Organic Letters, Issue 00027863, 2022, Page(s) 4722–4728, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.2c01402

Borylated cyclobutanes <i>via</i> thermal [2 + 2]-cycloaddition

Author(s): Kateryna Prysiazhniuk; Oleksandr Polishchuk; Stanislav Shulha; Kyrylo Gudzikevych; Oleksandr P. Datsenko; Vladimir Kubyshkin; Pavel K. Mykhailiuk
Published in: Chemical Science, Issue 1, 2024, Page(s) 3249-3254, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3sc06600b

2-Oxabicyclo[2.1.1]hexanes as saturated bioisosteres of the ortho-substituted phenyl ring

Author(s): Aleksandr Denisenko, Pavel Garbuz, Nataliya M. Voloshchuk, Yuliia Holota, Galeb Al-Maali, Petro Borysko, Pavel K. Mykhailiuk
Published in: Nature Chemistry, Issue 3, 2023, Page(s) 1155-1163, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-023-01222-0

2-Oxabicyclo[2.1.1]hexanes: synthesis, properties and validation as bioisosteres of ortho- and meta-Benzenes

Author(s): Vadym V. Levterov, Yaroslav Panasiuk, Oleh Shablykin, Oleksandr Stashkevych, Kateryna Sahun, Artur Rassokhin, Iryna Sadkova, Dmytro Lesyk, Anna Anisiforova, Yuliia Holota, Petro Borysko, Iryna Bodenchuk, Nataliya M. Voloshchuk
Published in: Angewandte Chemie International Edition, Issue 3, 2024, Page(s) e202319831, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202319831

Spiro[3.3]heptane as a Saturated Benzene Bioisostere**

Author(s): Kateryna Prysiazhniuk; Oleksandr P. Datsenko; Oleksandr Polishchuk; Stanislav Shulha; Oleh Shablykin; Yelyzaveta Nikandrova; Kateryna Horbatok; Iryna Bodenchuk; Petro Borysko; Dmytro Shepilov; Iryna Pishel; Vladimir Kubyshkin; Pavel K. Mykhailiuk
Published in: Angewandte Chemie International Edition, Issue 3, 2024, Page(s) e202316557, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202316557

General Synthesis of 3-Azabicyclo[3.1.1]heptanes and Evaluation of Their Properties as Saturated Isosteres

Author(s): Dmitry Dibchak, Mariya Snisarenko, Artem Mishuk, Oleh Shablykin, Lina Bortnichuk, Oleksii Klymenko-Ulianov, Yurii Kheylik, Iryna V. Sadkova, Henry S. Rzepa, Pavel K. Mykhailiuk
Published in: Angewandte Chemie International Edition, Issue 3, 2023, Page(s) e202304246, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202304246

A Practical and Scalable Approach to Fluoro-Substituted Bicyclo[1.1.1]pentanes

Author(s): Roman Bychek, Pavel K. Mykhailiuk
Published in: Angewandte Chemie International Edition, Issue 14337851, 2022, Page(s) e202205103, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202205103

Large-Scale Synthesis and Modifications of Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid (BCP)

Author(s): Vasyl Ripenko, Daniil Vysochyn, Ivan Klymov, Serhii Zhersh, Pavel K. Mykhailiuk
Published in: The Journal of Organic Chemistry, Issue 00223263, 2021, Page(s) 14061–14068, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.1c00977

Rapid and scalable halosulfonylation of strain-release reagents

Author(s): Helena D. Pickford, Vasyl Ripenko, Ryan E. McNamee, Serhii Holovchuk, Amber L. Thompson, Russell C. Smith, Pavel K. Mykhailiuk, Edward Alexander Anderson
Published in: Angewandte Chemie International Edition, Issue 14337851, 2022, Page(s) n/a - n/a, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202213508

Oxa-spirocycles: synthesis, properties and applications.

Author(s): Kateryna Fominova; Taras Diachuk; Dmitry S. Granat; Taras Savchuk; Vladyslav Vilchynskyi; Oleksiy Svitlychnyi; Vladyslav Meliantsev; Igor Kovalchuk; Eduard Litskan; Vadym V. Levterov; Valentyn R. Badlo; Ruslan I. Vaskevych; Alla I. Vaskevych; Andrii V. Bolbut; Volodymyr V. Semeno; Rustam T. Iminov; Kostiantyn Shvydenko; Anastasiia S. Kuznetsova; Yurii V. Dmytriv; Yurii V. Dmytriv; Daniil Vysochyn;
Published in: Chemical Science, Issue 14737604, 2021, Page(s) 11294-11305, ISSN 1473-7604
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sc03615g

The LARGEST library of Bicyclo[1.1.1]pentanes for Drug Discovery enabled by Light

Author(s): Vasyl Ripenko, Vadym Sham, Vitalina Levchenko, Serhii Holovchuk, Daniil Vysochyn, Ivan Klymov, Dmytro Kyslyi, Stanislav Veselovych, Serhii Zhersh, Yurii Dmytriv, Andrey Tolmachov, Iryna Sadkova, Irina Pishel, Pavel Mykhailiuk
Published in: ChemRxiv, Issue 5, 2023, ISSN 2573-2293
Publisher: Cambridge Open Engage
DOI: 10.26434/chemrxiv-2023-8dclm

1,2-Disubstituted Bicyclo[2.1.1]hexanes as Saturated Bioisosteres of the ortho-substituted Benzene

Author(s): Aleksandr Denisenko, Pavel Garbuz, Yelyzaveta Makovetska, Oleh Shablykin, Dmytro Lesyk, Galeb Al-Maali, Rodion Korzh, Iryna V. Sadkova and Pavel K. Mykhailiuk
Published in: Chemical Science, Issue 3, 2023, Page(s) accepted, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3sc05121h

2-Oxabicyclo[2.2.2]octane as a new bioisostere of the phenyl ring

Author(s): Vadym V. Levterov, Yaroslav Panasiuk, Kateryna Sahun, Oleksandr Stashkevych, Valentyn Badlo, Oleh Shablykin, Iryna Sadkova, Lina Bortnichuk, Oleksii Klymenko-Ulianov, Yuliia Holota, Leonid Lachmann, Petro Borysko, Kateryna Horbatok, Iryna Bodenchuk, Yuliia Bas, Dmytro Dudenko, Pavel K. Mykhailiuk
Published in: Nature Communications, Issue 3, 2023, Page(s) 5608, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-41298-3

https://onlinelibrary.wiley.com/doi/10.1002/anie.202311583

Author(s): Alexander Kirichok, Hennadii Tkachuk, Yevhenii Kozyriev, Oleh Shablykin, Oleksandr Datsenko, Dmitry Granat, Tetyana Yegorova, Yuliya Bas, Vitalii Semirenko, Iryna Pishel, Vladimir Kubyshkin, Oleksii Klymenko-Ulianov, Dmytro Lesyk, Pavel K. Mykhailiuk
Published in: Angewandte Chemie International Edition, Issue 3, 2023, Page(s) e202311583, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202311583

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