Deciphering the role of RNA modifications during ribosomal decoding and protein synthesis

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Functional divergence of the two Elongator subcomplexes during neurodevelopment

Author(s): Monika Gaik; Marija Kojic; Megan R Stegeman; Tülay Öncü‐Öner; Anna Kościelniak; Alun Jones; Ahmed Mohamed; Pak Yan Stefanie Chau; Sazia Sharmin; Andrzej Chramiec‐Głąbik; Paulina Indyka; Michał Rawski; Anna Biela; Dominika Dobosz; Amanda Millar; Vann Chau; Aycan Ünalp; Michael Piper; Mark C Bellingham; Evan E Eichler; Deborah A Nickerson; Handan Güleryüz; Nour El Hana Abbassi; Konrad
Published in: EMBO Molecular Medicine, Issue Volume 14, Issue 7, 2022, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202115608

It takes two to tRNAgo

Author(s): Igor Kaczmarczyk; Łukasz Koziej; Sebastian Glatt
Published in: Structure, Issue Volume 32, Issue 3, 2024, ISSN 0969-2126
Publisher: Cell Press
DOI: 10.1016/j.str.2024.02.005

Pseudouridines in RNAs: switching atoms means shifting paradigms.

Author(s): Ting-Yu Lin; Rahul Mehta; Sebastian Glatt
Published in: FEBS Letters, Issue 595, 2021, ISSN 1873-3468
Publisher: John Wiley & Sons Ltd
DOI: 10.1002/1873-3468.14188

Cryo-EM structure of the fully assembled Elongator complex

Author(s): Marcin Jaciuk; David Scherf; Karol Kaszuba; Monika Gaik; Alexander Rau; Anna Kościelniak; Rościsław Krutyhołowa; Michał Rawski; Paulina Indyka; Andrea Graziadei; Andrzej Chramiec-Głąbik; Anna Biela; Dominika Dobosz; Ting-Yu Lin; Nour-el-Hana Abbassi; Alexander Hammermeister; Juri Rappsilber; Jan Kosinski; Raffael Schaffrath; Sebastian Glatt
Published in: Nucleic Acids Research, 2023, ISSN 1362-4962
Publisher: Oxford University Press
DOI: 10.1093/nar/gkac1232

Cryo-EM structures of the human Elongator complex at work

Author(s): Nour-el-Hana Abbassi, Marcin Jaciuk, David Scherf, Pauline Böhnert, Alexander Rau, Alexander Hammermeister, Michał Rawski, Paulina Indyka, Grzegorz Wazny, Andrzej Chramiec-Głąbik, Dominika Dobosz, Bozena Skupien-Rabian, Urszula Jankowska, Juri Rappsilber, Raffael Schaffrath, Ting-Yu Lin, Sebastian Glatt
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-48251-y

Elongator and the role of its subcomplexes in human diseases

Author(s): Monika Gaik; Marija Kojic; Brandon J Wainwright; Sebastian Glatt
Published in: EMBO Molecular Medicine, Issue 1, 2022, Page(s) 1757-4676, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202216418

Destabilization of mutated human PUS3 protein causes intellectual disability

Author(s): Ting-Yu Lin, Robert Smigiel, Bozena Kuzniewska, Joanna J. Chmielewska, Joanna Kosińska, Mateusz Biela, Anna Biela, Anna Kościelniak, Dominika Dobosz, Izabela Laczmanska, Andrzej Chramiec-Głąbik, Jakub Jeżowski, Jakub Nowak, Monika Gos, Sylwia Rzonca-Niewczas, Magdalena Dziembowska, Rafał Ploski, Sebastian Glatt
Published in: Human Mutation, 2022, Page(s) 2063-2078, ISSN 1098-1004
Publisher: John Wiley & Sons
DOI: 10.1002/humu.24471

A novel ELP1 mutation impairs the function of the Elongator complex and causes a severe neurodevelopmental phenotype

Author(s): Marija Kojic, Nour E. H. Abbassi, Ting-Yu Lin, Alun Jones, Emma L. Wakeling, Emma Clement, Vasiliki Nakou, Matthew Singleton, Dominika Dobosz, Marios Kaliakatsos, Sebastian Glatt & Brandon J. Wainwright
Published in: J Hum Genet, 2023, Page(s) 445-453, ISSN 1434-5161
Publisher: Springer Verlag
DOI: 10.1038/s10038-023-01135-3

The diverse structural modes of tRNA binding and recognition

Author(s): Anna Biela; Alexander Hammermeister; Igor Kaczmarczyk; Marta Walczak; Lukasz Koziej; Ting-Yu Lin; Sebastian Glatt
Published in: Journal of biological chemistry, 2023, Page(s) 104966, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2023.104966

Modulation of translational decoding by m6A modification of mRNA

Author(s): Sakshi Jain, Lukasz Koziej, Panagiotis Poulis, Igor Kaczmarczyk, Monika Gaik, Michal Rawski, Namit Ranjan, Sebastian Glatt, Marina V Rodnina
Published in: Nature Communications, 2023, Page(s) 4784, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-40422-7

E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation.

Author(s): Keerthiraju E Ravichandran; Lars Kaduhr; Bozena Skupien‐Rabian; Ekaterina Shvetsova; Mikołaj Sokołowski; Ros´cisław Krutyhołowa; Dominika Kwasna; Cindy Brachmann; Sean Lin; Sebastian Guzman Perez; Piotr Wilk; Manuel Kösters; Przemysław Grudnik; Urszula Jankowska; Sebastian A Leidel; Raffael Schaffrath; Sebastian Glatt
Published in: The EMBO Journal, 2022, ISSN 1460-2075
Publisher: John Wiley & Sons, Ltd
DOI: 10.48350/173059

Ncs2* mediates <i>in vivo</i> virulence of pathogenic yeast through sulphur modification of cytoplasmic transfer RNA

Author(s): Fiona Alings; Karin Scharmann; Cristian Eggers; Bettina Böttcher; Mikołaj Sokołowski; Ekaterina Shvetsova; Puneet Sharma; Joël Roth; Leon Rashiti; Sebastian Glatt; Sascha Brunke; Sebastian A Leidel
Published in: Nucleic Acids Research, Issue 51(15), 2023, Page(s) 8133-8149, ISSN 1362-4962
Publisher: Oxford University Press
DOI: 10.1093/nar/gkad564

3-Mercaptopyruvate sulfur transferase is a protein persulfidase

Author(s): Brandán Pedre; Deepti Talwar; Uladzimir Barayeu; Danny Schilling; Marcin Luzarowski; Mikolaj Sokolowski; Sebastian Glatt; Tobias P. Dick
Published in: Nature Chemical Biology, Issue 1, 2023, Page(s) 507–517, ISSN 1552-4469
Publisher: Springer Nature
DOI: 10.1038/s41589-022-01244-8

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