Tumor-lock: forbid the generation of circulating tumor cells

Project Information

TUMOR-LOCK

Grant agreement ID: 101001652

DOI

10.3030/101001652

EC signature date 13 April 2021

Start date 1 June 2021

End date 31 May 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 995,00

EU contribution

€ 1 999 995,00

Coordinated by

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Thesis and dissertations (1)

Thermoplastic microfluidic devices for the analysis of cancer biomarkers in liquid biopsies

Author(s): Kling, André
Published in: Issue 1, 2022
Publisher: ETH Zurich
DOI: 10.3929/ethz-b-000585107

Peer reviewed articles (13)

Travelling under pressure-hypoxia and shear stress in the metastatic journey

Author(s): Ildiz, Ece Su; Gvozdenovic, Ana; Kovacs, Werner; Aceto, Nicola
Published in: Clinical & Experimental Metastasis, 40 (5), Issue 2, 2023, ISSN 0262-0898
Publisher: Kluwer Academic Publishers
DOI: 10.3929/ethz-b-000626511

Mutant SF3B1 promotes malignancy in PDAC

Author(s): Patrik Simmler; Eleonora I Ioannidi; Tamara Mengis; Kim Fabiano Marquart; Simran Asawa; Kjong Van-Lehmann; Andre Kahles; Tinu Thomas; Cornelia Schwerdel; Nicola Aceto; Gunnar Rätsch; Markus Stoffel; Gerald Schwank
Published in: eLife, 12, Issue 1, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.80683

MyCTC chip: microfluidic-based drug screen with patient-derived tumour cells from liquid biopsies

Author(s): Schwab, Fabienne D; Scheidmann, Manuel C; Ozimski, Lauren L; Kling, André; Armbrecht, Lucas; Ryser, Till; Krol, Ilona; Strittmatter, Karin; Nguyen-Sträuli, Bich Doan; Jacob, Francis; Fedier, André; Heinzelmann-Schwarz, Viola; Wicki, Andreas; Dittrich, Petra S; Aceto, Nicola
Published in: Microsystems & Nanoengineering (2022) 8:130, 2022, ISSN 2055-7434
Publisher: Nature Publishing group
DOI: 10.1038/s41378-022-00467-y

StealTHY: An immunogen-free CRISPR platform to expose concealed metastasis regulators in immunocompetent models

Author(s): Massimo Saini, Francesc Castro-Giner, Adriana Hotz, Magdalena K. Sznurkowska, Manuel Nüesch, François M. Cuenot, Selina Budinjas, Gilles Bilfeld, Ece Su Ildız, Karin Strittmatter, Ilona Krol, Zoi D
Published in: Cell, 2025, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2025.10.007

The metastatic spread of breast cancer accelerates during sleep

Author(s): Diamantopoulou, Zoi Castro-Giner, Francesc Schwab, Fabienne Dominique Foerster, Christiane Saini, Massimo Budinjas, Selina Strittmatter, Karin Krol, Ilona Seifert, Bettina Heinzelmann-Schwarz, Viola Kurzeder, Christian Rochlitz, Christoph Vetter, Marcus Weber, Walter Paul Aceto, Nicola
Published in: Nature, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04875-y

A new time dimension in the fight against metastasis

Author(s): Zoi Diamantopoulou, Ana Gvozdenovic, Nicola Aceto
Published in: Trends in Cell Biology, Issue 33, 2024, Page(s) 736-748, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2023.02.002

Biology, vulnerabilities and clinical applications of circulating tumour cells

Author(s): Alexander Ring, Bich Doan Nguyen-Sträuli, Andreas Wicki, Nicola Aceto
Published in: Nature Reviews Cancer, 23, 2023, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/s41568-022-00536-4

Macrovascular tumor infiltration and circulating tumor cell cluster dynamics in patients with cancer approaching the end of life

Author(s): Kelley Newcomer, Alessandro Bifolco, Sarah Reeves, Giada Pontecorvi, Simran Asawa, Magdalena K. Sznurkowska, Manuel Nüesch, Lauren L. Ozimski, Louisa Bolm, Malte Maria Sieren, Lukas Müller, Zhikai C
Published in: Nature Medicine, 2025, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-025-03966-3

An <i>In Vivo</i> CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression

Author(s): Manuel C. Scheidmann; Francesc Castro-Giner; Karin Strittmatter; Ilona Krol; Aino Paasinen-Sohns; Ramona Scherrer; Cinzia Donato; Sofia Gkountela; Barbara M. Szczerba; Zoi Diamantopoulou; Simone Muenst; Tatjana Vlajnic; Leo Kunz; Marcus Vetter; Christoph Rochlitz; Verdon Taylor; Claudio Giachino; Timm Schroeder; Randall J. Platt; Nicola Aceto
Published in: Cancer Res, Issue 1, 2022, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-21-3908

Circulating tumour cells in gastrointestinal cancers: food for thought?

Author(s): Simran Asawa, Manuel Nüesch, Ana Gvozdenovic, Nicola Aceto
Published in: British Journal of Cancer volume 128, 2023, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-023-02228-8

Phylogenetic inference reveals clonal heterogeneity in circulating tumor cell clusters

Author(s): David Gremmelspacher, Johannes Gawron, Barbara M. Szczerba, Katharina Jahn, Francesc Castro-Giner, Jack Kuipers, Jochen Singer, Francesco Marass, Ana Gvozdenovic, Selina Budinjas, Heike Pueschel, Cyri
Published in: Nature Genetics, Issue 57, 2025, Page(s) 1357-1361, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-025-02205-2

Digoxin for reduction of circulating tumor cell cluster size in metastatic breast cancer: a proof-of-concept trial

Author(s): Christian Kurzeder, Bich Doan Nguyen-Sträuli, Ilona Krol, Alexander Ring, Francesc Castro-Giner, Manuel Nüesch, Simran Asawa, Yu Wei Zhang, Selina Budinjas, Ana Gvozdenovic, Maren Vogel, Angela Kohl
Published in: Nature Medicine, Issue 31, 2025, Page(s) 1120-1124, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-024-03486-6

Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer

Author(s): Massimo Saini, Laura Schmidleitner, Helena Domínguez Moreno, Elisa Donato, Mattia Falcone, Johanna M Bartsch, Corinna Klein, Vanessa Vogel, Roberto Würth, Nicole Pfarr, Elisa Espinet, Mareike Lehmann, Melanie Königshoff, Manuel Reitberger, Simon Haas, Elisabeth Graf, Thomas Schwarzmayr, Tim-Matthias Strom, Saskia Spaich, Marc Sütterlin, Andreas Schneeweiss, Wilko Weichert, Gunnar Schotta, Maxi
Published in: Cell Reports 42,112533, 2023, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.112533

Non-peer reviewed articles (2)

Alone you go faster, together you go farther

Author(s): Nicola Aceto
Published in: Molecular Oncology, Issue 1, 2023, ISSN 1878-0261
Publisher: John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies
DOI: 10.1002/1878-0261.13549

A growing entourage for heterotypic circulating tumor cell clusters

Author(s): Ana Gvozdenovic, Nicola Aceto
Published in: Trends in Cancer, Issue 11, 2025, Page(s) 1137-1138, ISSN 2405-8033
Publisher: Elsevier BV
DOI: 10.1016/j.trecan.2025.10.006