Tumor-lock: forbid the generation of circulating tumor cells

Información del proyecto

TUMOR-LOCK

Identificador del acuerdo de subvención: 101001652

DOI

10.3030/101001652

Proyecto cerrado

Fecha de la firma de la CE 13 Abril 2021

Fecha de inicio 1 Junio 2021

Fecha de finalización 31 Mayo 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 999 995,00

Aportación de la UE

€ 1 999 995,00

Coordinado por

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Thesis and dissertations (1)

Thermoplastic microfluidic devices for the analysis of cancer biomarkers in liquid biopsies

Autores: Kling, André
Publicado en: Edición 1, 2022
Editor: ETH Zurich
DOI: 10.3929/ethz-b-000585107

Peer reviewed articles (22)

Travelling under pressure-hypoxia and shear stress in the metastatic journey

Autores: Ildiz, Ece Su; Gvozdenovic, Ana; Kovacs, Werner; Aceto, Nicola
Publicado en: Clinical & Experimental Metastasis, 40 (5), Edición 2, 2023, ISSN 0262-0898
Editor: Kluwer Academic Publishers
DOI: 10.3929/ethz-b-000626511

Mutant SF3B1 promotes malignancy in PDAC

Autores: Patrik Simmler; Eleonora I Ioannidi; Tamara Mengis; Kim Fabiano Marquart; Simran Asawa; Kjong Van-Lehmann; Andre Kahles; Tinu Thomas; Cornelia Schwerdel; Nicola Aceto; Gunnar Rätsch; Markus Stoffel; Gerald Schwank
Publicado en: eLife, 12, Edición 1, 2023, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.80683

MyCTC chip: microfluidic-based drug screen with patient-derived tumour cells from liquid biopsies

Autores: Schwab, Fabienne D; Scheidmann, Manuel C; Ozimski, Lauren L; Kling, André; Armbrecht, Lucas; Ryser, Till; Krol, Ilona; Strittmatter, Karin; Nguyen-Sträuli, Bich Doan; Jacob, Francis; Fedier, André; Heinzelmann-Schwarz, Viola; Wicki, Andreas; Dittrich, Petra S; Aceto, Nicola
Publicado en: Microsystems & Nanoengineering (2022) 8:130, 2022, ISSN 2055-7434
Editor: Nature Publishing group
DOI: 10.1038/s41378-022-00467-y

First-in-human administration of [161Tb]Tb-SibuDAB and comparative dosimetry with standard [177Lu]Lu-PSMA-I&T as part of the PROGNOSTICS phase Ia study

Autores: Alin Chirindel, Guillaume P. Nicolas, Frida Westerbergh, Lisa McDougall, David E. Schmid, Susanne Geistlich, Viviane J. Tschan, Sarah D. Busslinger, Angelique Fokkema, Nicola Aceto, Peter Bernhardt, Nicholas P. van der Meulen, Cristina Müller, Damian Wild, Roger Schibli
Publicado en: European Journal of Nuclear Medicine and Molecular Imaging, Edición 52, 2025, Página(s) 1628-1630, ISSN 1619-7070
Editor: Springer Verlag
DOI: 10.1007/s00259-024-07009-w

StealTHY: An immunogen-free CRISPR platform to expose concealed metastasis regulators in immunocompetent models

Autores: Massimo Saini, Francesc Castro-Giner, Adriana Hotz, Magdalena K. Sznurkowska, Manuel Nüesch, François M. Cuenot, Selina Budinjas, Gilles Bilfeld, Ece Su Ildız, Karin Strittmatter, Ilona Krol, Zoi D
Publicado en: Cell, 2025, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2025.10.007

Pulmonary Tumor Thrombotic Microangiopathy in a Patient with Rapid Progressive Triple-Negative Breast Cancer

Autores: Fiona Rudolf, Albert Baschong, Deniz Bilecen, Nicola Aceto, Marcus Vetter
Publicado en: Case Reports in Oncology, Edición 17, 2025, Página(s) 277-282, ISSN 1662-6575
Editor: Karger AG
DOI: 10.1159/000535873

The metastatic spread of breast cancer accelerates during sleep

Autores: Diamantopoulou, Zoi Castro-Giner, Francesc Schwab, Fabienne Dominique Foerster, Christiane Saini, Massimo Budinjas, Selina Strittmatter, Karin Krol, Ilona Seifert, Bettina Heinzelmann-Schwarz, Viola Kurzeder, Christian Rochlitz, Christoph Vetter, Marcus Weber, Walter Paul Aceto, Nicola
Publicado en: Nature, 2022, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-022-04875-y

A new time dimension in the fight against metastasis

Autores: Zoi Diamantopoulou, Ana Gvozdenovic, Nicola Aceto
Publicado en: Trends in Cell Biology, Edición 33, 2024, Página(s) 736-748, ISSN 0962-8924
Editor: Elsevier BV
DOI: 10.1016/j.tcb.2023.02.002

Biology, vulnerabilities and clinical applications of circulating tumour cells

Autores: Alexander Ring, Bich Doan Nguyen-Sträuli, Andreas Wicki, Nicola Aceto
Publicado en: Nature Reviews Cancer, 23, 2023, ISSN 1474-175X
Editor: Nature Publishing Group
DOI: 10.1038/s41568-022-00536-4

Macrovascular tumor infiltration and circulating tumor cell cluster dynamics in patients with cancer approaching the end of life

Autores: Kelley Newcomer, Alessandro Bifolco, Sarah Reeves, Giada Pontecorvi, Simran Asawa, Magdalena K. Sznurkowska, Manuel Nüesch, Lauren L. Ozimski, Louisa Bolm, Malte Maria Sieren, Lukas Müller, Zhikai C
Publicado en: Nature Medicine, 2025, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-025-03966-3

An <i>In Vivo</i> CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression

Autores: Manuel C. Scheidmann; Francesc Castro-Giner; Karin Strittmatter; Ilona Krol; Aino Paasinen-Sohns; Ramona Scherrer; Cinzia Donato; Sofia Gkountela; Barbara M. Szczerba; Zoi Diamantopoulou; Simone Muenst; Tatjana Vlajnic; Leo Kunz; Marcus Vetter; Christoph Rochlitz; Verdon Taylor; Claudio Giachino; Timm Schroeder; Randall J. Platt; Nicola Aceto
Publicado en: Cancer Res, Edición 1, 2022, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-21-3908

Simulating the Effect of Removing Circulating Tumor Cells (CTCs) from Blood Reveals That Only Implantable Devices Can Significantly Reduce Metastatic Burden of Patients

Autores: Werner Baumgartner, Nicola Aceto, Sebastian Lifka
Publicado en: Cancers, Edición 16, 2025, Página(s) 3078, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers16173078

Ki-67 promotes circulating tumor cell intravasation and metastasis in breast cancer

Autores: Yongzhan Zhang, Jianwen Zhou, Karin Strittmatter, Yu Wei Zhang, Maria Waldmeier, Simran Asawa, Marko Vujanovic, Selina Budinjas, Massimo Saini, Ece Su Ildiz, Ana Gvozdenovic, Werner Kovacs, Francesc Castro-Giner, Nicola Aceto
Publicado en: Cell Reports, Edición 45, 2026, Página(s) 117354, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2026.117354

Site-directed conjugation of single-stranded DNA to affinity proteins: quantifying the importance of conjugation strategy

Autores: Andres Rocha Tapia, Fabrice Abgottspon, Johan Nilvebrant, Per-Åke Nygren, Sarah Duclos Ivetich, Andres Javier Bello Hernandez, Ioanna A. Thanasi, Peter A. Szijj, Ghali Sekkat, François M. Cuenot, Vi
Publicado en: Chemical Science, Edición 15, 2024, Página(s) 8982-8992, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d4sc01838a

Circulating tumour cells in gastrointestinal cancers: food for thought?

Autores: Simran Asawa, Manuel Nüesch, Ana Gvozdenovic, Nicola Aceto
Publicado en: British Journal of Cancer volume 128, 2023, ISSN 0007-0920
Editor: Nature Publishing Group
DOI: 10.1038/s41416-023-02228-8

Phylogenetic inference reveals clonal heterogeneity in circulating tumor cell clusters

Autores: David Gremmelspacher, Johannes Gawron, Barbara M. Szczerba, Katharina Jahn, Francesc Castro-Giner, Jack Kuipers, Jochen Singer, Francesco Marass, Ana Gvozdenovic, Selina Budinjas, Heike Pueschel, Cyri
Publicado en: Nature Genetics, Edición 57, 2025, Página(s) 1357-1361, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-025-02205-2

Digoxin for reduction of circulating tumor cell cluster size in metastatic breast cancer: a proof-of-concept trial

Autores: Christian Kurzeder, Bich Doan Nguyen-Sträuli, Ilona Krol, Alexander Ring, Francesc Castro-Giner, Manuel Nüesch, Simran Asawa, Yu Wei Zhang, Selina Budinjas, Ana Gvozdenovic, Maren Vogel, Angela Kohl
Publicado en: Nature Medicine, Edición 31, 2025, Página(s) 1120-1124, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-024-03486-6

Dual-positive CTCs in patients with advanced breast cancer show metastatic potential and prognostic value

Autores: Carolina Reduzzi, Eleonora Nicolò, Lorenzo Gerratana, Lauren L. Ozimski, Marco Silvestri, Youbin Zhang, David Scholten, Mara S. Serafini, Maroua Manai, Paolo D’Amico, Elisabetta Molteni, Nadia Bayou, Brenno Pastò, Massimo Saini, Andrew A. Davis, Serena Di Cosimo, Vera Cappelletti, Huiping Liu, William J. Gradishar, Nicola Aceto, Massimo Cristofanilli
Publicado en: Science Translational Medicine, Edición 18, 2026, ISSN 1946-6234
Editor: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.adw7698

A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells

Autores: Yu Wei Zhang, Ana Gvozdenovic, Nicola Aceto
Publicado en: Cancer Discovery, Edición 14, 2024, Página(s) 920-933, ISSN 2159-8274
Editor: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-24-0218

Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer

Autores: Massimo Saini, Laura Schmidleitner, Helena Domínguez Moreno, Elisa Donato, Mattia Falcone, Johanna M Bartsch, Corinna Klein, Vanessa Vogel, Roberto Würth, Nicole Pfarr, Elisa Espinet, Mareike Lehmann, Melanie Königshoff, Manuel Reitberger, Simon Haas, Elisabeth Graf, Thomas Schwarzmayr, Tim-Matthias Strom, Saskia Spaich, Marc Sütterlin, Andreas Schneeweiss, Wilko Weichert, Gunnar Schotta, Maxi
Publicado en: Cell Reports 42,112533, 2023, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2023.112533

Novel Cell Cycle Inhibitors Decrease Primary and Metastatic Breast Cancer Growth In Vivo

Autores: Mir Shahid Maqbool, Yongzhan Zhang, Karin Strittmatter, Ana Gvozdenovic, Simran Asawa, Masroor A. Paddar, Mukesh Kumar, Umed Singh, Parvinder Pal Singh, Nicola Aceto, Fayaz Malik
Publicado en: Cancers, Edición 18, 2026, Página(s) 466, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers18030466

PDL1-expressing macrophages infiltrate diffuse large B-cell lymphoma and promote lymphoma growth in a MYC-driven experimental model

Autores: Ningxuan Cui, Peter Leary, Vanesa-Sindi Ivanova, Kristin Stirm, Lydia Kirsche, Nicola Aceto, Frank Stenner, Lothar C. Dieterich, Michael Detmar, Ekaterina Petrova, Sarah Mundt, Melanie Greter, Alexandar Tzankov, Anne Müller
Publicado en: Blood Cancer Journal, Edición 15, 2025, ISSN 2044-5385
Editor: Nature Publishing Group
DOI: 10.1038/s41408-025-01281-1

Non-peer reviewed articles (2)

Alone you go faster, together you go farther

Autores: Nicola Aceto
Publicado en: Molecular Oncology, Edición 1, 2023, ISSN 1878-0261
Editor: John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies
DOI: 10.1002/1878-0261.13549

A growing entourage for heterotypic circulating tumor cell clusters

Autores: Ana Gvozdenovic, Nicola Aceto
Publicado en: Trends in Cancer, Edición 11, 2025, Página(s) 1137-1138, ISSN 2405-8033
Editor: Elsevier BV
DOI: 10.1016/j.trecan.2025.10.006