How antibodies and complement orchestrate protective immune responses against bacteria

Project Information

ACCENT

Grant agreement ID: 101001937

DOI

10.3030/101001937

EC signature date 16 February 2021

Start date 1 January 2022

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

A DMP will be written taking into account the most recent templates available The DMP will be updated when necessary and submitted together with periodic reports

Publications

Peer reviewed articles (8)

Klebsiella LPS O1-antigen prevents complement-mediated killing by inhibiting C9 polymerization

Author(s): Frerich M Masson, Salvör Káradóttir, Sjors PA van der Lans, Dennis J Doorduijn, Carla JC de Haas, Suzan HM Rooijakkers, Bart W Bardoel
Published in: Scientific Reports, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.21203/rs.3.rs-3934642/v1

Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation

Author(s): Douwe J. Dijkstra, Fleur S. van de Bovenkamp, Leoni Abendstein, Rob Zuijderduijn, Jos Pool, Cynthia S. M. Kramer, Linda M. Slot, Jan W. Drijfhout, Lisanne de Vor, Kyra A. Gelderman, Suzan H. M. Rooijakkers, Arnaud Zaldumbide, Gestur Vidarsson, Thomas H. Sharp, Paul W. H. I. Parren, Leendert A. Trouw
Published in: Proceedings of the National Academy of Sciences, Issue 120, 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2310666120

Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria

Author(s): Stian Foss, Siri A. Sakya, Leire Aguinagalde, Marta Lustig, Jutamas Shaughnessy, Ana Rita Cruz, Lisette Scheepmaker, Line Mathiesen, Fulgencio Ruso-Julve, Aina Karen Anthi, Torleif Tollefsrud Gjølberg, Simone Mester, Malin Bern, Mitchell Evers, Diane B. Bratlie, Terje E. Michaelsen, Tilman Schlothauer, Devin Sok, Jayanta Bhattacharya, Jeanette Leusen, Thomas Valerius, Sanjay Ram, Suzan H. M. Rooi
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-46321-9

Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies

Author(s): Eva M. Struijf, Karla I De la O Becerra, Maartje Ruyken, Fleur van Oosterom, Danique Y. Siere, Dani A. C. Heesterbeek, Edward Dolk, Raimond Heukers, Bart W. Bardoel, Piet Gros, Suzan H.M. Rooijakkers
Published in: Journal of Biological Chemistry, 2023, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2023.104956

Artificial surface labelling of Escherichia coli with StrepTagII antigen to study how monoclonal antibodies drive complement-mediated killing

Author(s): Remy M. Muts, Maurits A. den Boer, Bart W. Bardoel, Piet C. Aerts, Carla J. C. de Haas, Albert J. R. Heck, Suzan H. M. Rooijakkers, Dani A. C. Heesterbeek
Published in: Scientific Reports, Issue 13, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-46026-x

Single-cell Sequencing of Circulating Human Plasmablasts during <i>Staphylococcus aureus</i> Bacteremia

Author(s): Priscilla F. Kerkman, Lisanne de Vor, Thomas W. van der Vaart, Thijs ten Doesschate, Remy M. Muts, Jamie S. Depelteau, Lisette M. Scheepmaker, Maartje Ruyken, Carla J. C. de Haas, Piet C. Aerts, Renoud J. Marijnissen, Janine Schuurman, Frank J. Beurskens, Andrea Gorlani, Bart W. Bardoel, Suzan H. M. Rooijakkers
Published in: The Journal of Immunology, 2024, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.2300858

Promoting Fc-Fc interactions between anti-capsular antibodies provides strong immune protection against <i>Streptococcus pneumoniae</i>

Author(s): Aguinagalde Salazar, Leire; den Boer, Maurits A; Castenmiller, Suzanne M; Zwarthoff, Seline A; de Haas, Carla; Aerts, Piet C; Beurskens, Frank J; Schuurman, Janine; Heck, Albert J R; van Kessel, Kok; Rooijakkers, Suzan H M; Afd Biomol.Mass Spect. and Proteomics; Sub Biomol.Mass Spectrometry & Proteom.; Biomolecular Mass Spectrometry and Proteomics; Biomolecular Mass Spectrometry and Proteomics
Published in: eLife, 12. eLife Sciences Publications, Issue 2, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.80669

Agnostic B cell selection approach identifies antibodies against K. pneumoniae that synergistically drive complement activation

Author(s): Sjors P. A. van der Lans, Bart W. Bardoel, Maartje Ruyken, Carla J. C. de Haas, Stan Baijens, Remy M. Muts, Lisette M. Scheepmaker, Piet C. Aerts, Marije F. L. van ’t Wout, Johannes Preiner, Renoud J. Marijnissen, Janine Schuurman, Frank J. Beurskens, Priscilla F. Kerkman, Suzan H. M. Rooijakkers
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-52372-9